{"created":"2023-07-27T06:53:43.343167+00:00","id":48565,"links":{},"metadata":{"_buckets":{"deposit":"9295b962-f9ea-430d-9a27-7a6213419f09"},"_deposit":{"created_by":18,"id":"48565","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"48565"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00048565","sets":["2812:2813:2817"]},"author_link":["86440","86441"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-09-08","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2014-04-01 - 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、免疫系の効果分子APOBECとヒト腫瘍ウイルスの代表であるパピローマウイルス(HPV)やB型肝炎ウイルス(HBV)との関係性を調べた。その結果、APOBECはHPVの粒子形成プロセスに干渉し、感染性を低下させ、あるいはウイルスDNAに変異を作る事が明らかになった。またAPOBECがHBVのウイルスRNAを破壊する活性を持つ事がわかった。\nこれらの研究により、免疫系の持つHBVやHPVに対する感染防御力の一つにAPOBECという宿主酵素群が関与する可能性が浮上し、その機構の一旦が明らかになった。","subitem_description_type":"Abstract"},{"subitem_description":"We investigated antiviral role of immune effecter molecules APOBEC in viral infection of papillomavirus (HPV) and hepatitis B virus (HBV). Experimental results suggest that APOBECs reduce infectivity of HPV16 pseudovirion by interfering viral assemble in vitro. DNA sequencing of clinical samples derived from precancerous cervixs revealed that APOBECs introduce hypermutation in HPV16 viral DNA. Mapping of mutation identifies viral promoter and replication origin as a hot spot of hypermutation mechanism. We also found that AID is induced in hepatocytes by TGFb stimulation and AID forms an RNP complex of viral P protein and host RNA exosome, resulting in degradation of HBV RNA. These studies demonstrate significant role of APOBEC protein in HPV and HBV infection.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26293103, 研究期間(年度):2014-04-01 - 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「遺伝子改編酵素群APOBECの発ガンウイルス感染における役割」研究成果報告書　課題番号26293103\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26293103/26293103seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054887","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20359813"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20359813","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26293103/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26293103/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26293103/26293103seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26293103/26293103seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-11"}],"displaytype":"detail","filename":"ME-PR-MURAMATSU-M-kaken 2017-5p.pdf","filesize":[{"value":"266.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-MURAMATSU-M-kaken 2017-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/48565/files/ME-PR-MURAMATSU-M-kaken 2017-5p.pdf"},"version_id":"63cf39e3-0b42-4eee-abed-cd54abf92875"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"遺伝子改編酵素群APOBECの発ガンウイルス感染における役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"遺伝子改編酵素群APOBECの発ガンウイルス感染における役割"},{"subitem_title":"Role of APOBEC deaminases in human tumor virus infection","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-07-11"},"publish_date":"2019-07-11","publish_status":"0","recid":"48565","relation_version_is_last":true,"title":["遺伝子改編酵素群APOBECの発ガンウイルス感染における役割"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:13:30.463743+00:00"}