{"created":"2023-07-27T06:53:47.795164+00:00","id":48657,"links":{},"metadata":{"_buckets":{"deposit":"23cd279e-0ea3-481d-9bb3-47d34e151f6b"},"_deposit":{"created_by":18,"id":"48657","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"48657"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00048657","sets":["2812:2813:2822"]},"author_link":["2238","86569"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05-21","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2009-2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"B細胞成熟発達段階でのCD95誘導性細胞死システムの機能的役割を明らかにするために、B細胞の細胞表面形質, B細胞レパートワ解析などを検討した。正常ヒトの感染症発症後4. 7日後や自己免疫性疾患ではCD38陽性, IgD陰性, CD95陽性のメモリーB細胞, plasmablastと形質細胞を含むCD19陽性CD20陰性細胞の増加が認められた。自己免疫性疾患におけるB細胞発達段階でのCD95誘導性細胞死異常の存在が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"To examine the functional roles of CD95-induced apoptosis in B cell differentiation and maturation stages, B cell antigen expression and repertoire were analyzed. Increase of CD19-positive, CD20-negative cells including CD38 positive, IgD negative, CD95positive memory B cells, plasmablast and plasma cells were found in circulation in patients with infection and autoimmune disease. These results indicated that anomaly of CD95-induced apoptosis systems in B cell maturation may relate to the pathogenesis of autoimmune disease.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:21591352, 研究期間(年度):2009-2011","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「自己抗原特異的B細胞成熟分化段階におけるCD95誘導性細胞死システムの意義」課題番号21591352\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21591352/21591352seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域保健学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054979","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30204366"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30204366","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591352/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591352/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21591352/21591352seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21591352/21591352seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-22"}],"displaytype":"detail","filename":"ME-PR-KASAHARA-Y-kaken 2012-5p.pdf","filesize":[{"value":"218.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-KASAHARA-Y-kaken 2012-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/48657/files/ME-PR-KASAHARA-Y-kaken 2012-5p.pdf"},"version_id":"4e7453af-330f-4bd4-9192-fb7135c85159"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"自己抗原特異的B細胞成熟分化段階におけるCD95誘導性細胞死システムの意義","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"自己抗原特異的B細胞成熟分化段階におけるCD95誘導性細胞死システムの意義"},{"subitem_title":"The role of CD95-induced apoptosis system in the maturation and differentiation stages of self-antigen specific B cells","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-07-22"},"publish_date":"2019-07-22","publish_status":"0","recid":"48657","relation_version_is_last":true,"title":["自己抗原特異的B細胞成熟分化段階におけるCD95誘導性細胞死システムの意義"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:24:31.786332+00:00"}