{"created":"2023-07-27T06:53:47.839156+00:00","id":48658,"links":{},"metadata":{"_buckets":{"deposit":"dbfcca01-593c-455e-b63e-f2052fb93a0d"},"_deposit":{"created_by":18,"id":"48658","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"48658"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00048658","sets":["2812:2813:2825"]},"author_link":["2238","86569"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-04-06","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2007-2008","bibliographic_titles":[{"bibliographic_title":"平成20(2008)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2008 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"正常ヒトダブルネガティブ(DN)T細胞は自己免疫抑制調節性機能を持つが、自己免疫性リンパ球増殖症候群(Autoimmune Lymphoproliferative Syndrome : ALPS)において増加するDN T細胞ではCD95/CD95L細胞死誘導欠損により調節性T細胞(Treg)機能が低下し、自己免疫病態が拡大する。DNT細胞のTreg細胞としての特徴を正常およびALPS患者において比較解析した。ALPSのDNT細胞の細胞表面発現はCD7、CD62L、CD45RO発現が低下、CD4+Treg細胞と同様にIL-7R陰性で、CD57, CD38, CD95, HLA-DR, CD45RO陽性であった。一方、CD4+Treg細胞の特異的転写因子FoxP3蛋白発現は認められなかった。DNT細胞の培養後細胞死比率はALPS83%、健常人30%と有意にALPSにおいて有意に増加していた。DNT細胞のTCRレパートワ分布解析ではALPS14症例中5例(35.7%)、正常対照40例中3例(75%)にTCRVβの1種類以上のあきらかな増加を認めた。CDR3spectrum解析ではALPS11例(78.5%)、健常人全例で3種類以上のVβにoligo-clonal patternを認めた。また、ALPSの症状を有するがCD95誘導性細胞死が正常であったALPS III型と考えられていた症例4例のうち1例にモザイク型CD95変異が存在することを証明した。変異比率はDNT細胞では100%、他のリンパ球分画でも1-10%存在し、繊維芽細胞や口腔粘膜上皮細胞にも1%存在し、モザイク型の変異を初めて見出した。","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:19591243, 研究期間(年度):2007-2008","subitem_description_type":"Other"},{"subitem_description":"出典：「ダブルネガティブ調節性T細胞におけるCD95細胞死システムの意義」研究成果報告書　課題番号19591243\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19591243/19591243seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00054980","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域保健学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30204366"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30204366","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19591243/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19591243/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19591243/19591243seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19591243/19591243seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-22"}],"displaytype":"detail","filename":"ME-PR-KASAHARA-Y-kaken 2009-4p.pdf","filesize":[{"value":"333.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-KASAHARA-Y-kaken 2009-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/48658/files/ME-PR-KASAHARA-Y-kaken 2009-4p.pdf"},"version_id":"40af00e0-b4d2-4d74-8550-1ea68faf9ff8"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ダブルネガティブ調節性T細胞におけるCD95細胞死システムの意義","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ダブルネガティブ調節性T細胞におけるCD95細胞死システムの意義"},{"subitem_title":"Role of CD95-induced apoptotic system in double negative regulatory T cells","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2825"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-07-22"},"publish_date":"2019-07-22","publish_status":"0","recid":"48658","relation_version_is_last":true,"title":["ダブルネガティブ調節性T細胞におけるCD95細胞死システムの意義"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:13:13.063931+00:00"}