{"created":"2023-07-27T06:53:50.016643+00:00","id":48804,"links":{},"metadata":{"_buckets":{"deposit":"62cebdef-aef4-4836-9651-b0460642c21c"},"_deposit":{"created_by":18,"id":"48804","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"48804"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00048804","sets":["2812:2813:2817"]},"author_link":["86815","166"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05-12","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2014-04-01 - 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Iseki, Syoichi"}],"nameIdentifiers":[{"nameIdentifier":"86815","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50167251","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50167251"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"マウス顎下腺に見られる２種類の性差のうち，雄における顆粒性導管（GCT）細胞の優位な増加はアンドロゲン受容体（AR）の欠損マウス（ARKO）では起こらないのでARに依存すること，ARKOへの甲状腺ホルモン（T4）投与によりARと無関係にGCT細胞が増加することがわかった。一方，雄における顆粒性介在部導管（GID）細胞の優位な減少はARKOでは起こらず，ARKOへのT4投与でも変化しなかったので，両者は異なるホルモン依存性をもつことがわかった。また正常及びARKO顎下腺の遺伝子発現の網羅的解析により，GCT細胞に特異的な多くの遺伝子産物を同定した。","subitem_description_type":"Abstract"},{"subitem_description":"Of the two kinds of sexual dimorphism in the mouse submandibular gland (SMG), the preferential increase of granular convoluted tubule (GCT) cells in males was lacking in androgen receptor (AR)-deficient mice (ARKO) and, thus, proved to be dependent on AR, whereas the administration of thyroid hormone (T4) to ARKO caused increase of GCT cells independent of AR. On the other hand, the preferential decrease of granular intercalated duct (GID) cells in males was lacking in ARKO, and administration of T4 caused no decrease of GID cells, suggesting that the two kinds of sexual dimorphism have different hormone dependency. Furthermore, the gene expression profile of the normal and ARKO SMG identified numbers of new GCT-specific gene products.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26460270, 研究期間(年度):2014-04-01 - 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「ホルモンによるマウス顎下腺分化の分子機構」研究成果報告書　課題番号26460270\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26460270/26460270seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00055124","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50167251"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50167251","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26460270/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26460270/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26460270/26460270seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26460270/26460270seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"井関, 尚一"}],"nameIdentifiers":[{"nameIdentifier":"166","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50167251","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50167251"},{"nameIdentifier":"50167251","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000050167251"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-05"}],"displaytype":"detail","filename":"ME-PR-ISEKI-S-kaken 2017-5p.pdf","filesize":[{"value":"172.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-ISEKI-S-kaken 2017-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/48804/files/ME-PR-ISEKI-S-kaken 2017-5p.pdf"},"version_id":"5e3171d9-9dd4-4deb-b29e-4bb1243e93e6"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ホルモンによるマウス顎下腺分化の分子機構","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ホルモンによるマウス顎下腺分化の分子機構"},{"subitem_title":"Molecular mechanisms in the hormone-dependent differentiation of the mouse submandibular gland","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-08-05"},"publish_date":"2019-08-05","publish_status":"0","recid":"48804","relation_version_is_last":true,"title":["ホルモンによるマウス顎下腺分化の分子機構"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:39:16.339456+00:00"}