{"created":"2023-07-27T06:53:56.774252+00:00","id":49008,"links":{},"metadata":{"_buckets":{"deposit":"aed9dd77-c064-4597-bf7e-87f870bfd210"},"_deposit":{"created_by":18,"id":"49008","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"49008"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00049008","sets":["2812:2813:2815"]},"author_link":["87685","87686"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-05-15","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2016-04-01 – 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、種間および種内で多様性を示す免疫レセプターに着目し病原体との相互作用解析を通して感染症における免疫レセプターの役割の解明を目的とした。\n各種免疫レセプターの標的分子の探索を行ったところ、抑制化レセプターLILRB1が熱帯熱マラリア原虫感染赤血球の細胞表面に発現するRIFINを認識することで、B細胞およびNK細胞の機能を抑制し、マラリアの重症化との関連性が明らかとなった。","subitem_description_type":"Abstract"},{"subitem_description":"The aim of this study is to clarify the role of immune receptors with inter- and intraspecies diversity in infectious diseases.\nIn the process of search for interaction between pathogens and host immune receptors, it was found that inhibitory receptor LILRB1 recognized RIFINs expressed on P. falciparum-infected red blood cells. RIFINs inhibited activation of LILRB1-expressing B cells and natural killer (NK) cells. Furthermore, P. falciparum-infected erythrocytes isolated from patients with severe malaria were more likely to interact with LILRB1 than erythrocytes from patients with non-severe malaria, suggesting that LILRB1-RIFIN interaction may be involved in the development of severe malaria.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16K08839, 研究期間(年度):2016-04-01 – 2019-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「種間および種内において多様化した免疫受容体の感染症における役割」課題番号16K08839\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K08839/16K08839seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00055323","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学先進予防医学研究センター / 大阪大学"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30585170"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30585170","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K08839/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K08839/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K08839/16K08839seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K08839/16K08839seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-04-27"}],"displaytype":"detail","filename":"ME-PR-HIRAYASU-K-kaken 2019-5p.pdf","filesize":[{"value":"168.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-HIRAYASU-K-kaken 2019-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/49008/files/ME-PR-HIRAYASU-K-kaken 2019-5p.pdf"},"version_id":"179a2a27-920a-49ad-8d54-fcc2ae349823"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"種間および種内において多様化した免疫受容体の感染症における役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"種間および種内において多様化した免疫受容体の感染症における役割"},{"subitem_title":"The role of immune receptors with inter- and intraspecies diversity in infectious diseases","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-27"},"publish_date":"2020-04-27","publish_status":"0","recid":"49008","relation_version_is_last":true,"title":["種間および種内において多様化した免疫受容体の感染症における役割"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:32:47.534122+00:00"}