{"created":"2023-07-27T06:53:56.817963+00:00","id":49009,"links":{},"metadata":{"_buckets":{"deposit":"e2fc0bbf-24cd-4f4c-834f-e0d25a56dde8"},"_deposit":{"created_by":18,"id":"49009","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"49009"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00049009","sets":["2812:2813:2817"]},"author_link":["87685","87686"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05-31","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2014-04-01 – 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、免疫レセプターと様々な病原体との相互作用を網羅的に調べた。その結果、活性化レセプターLILRA2が病原微生物によって破壊された抗体を認識し病原微生物に対して生体防御を行っていることが明らかとなった。この結果から、病原微生物は宿主の免疫から逃れるために様々な免疫逃避機構を進化させてきた一方で、宿主側は病原微生物による免疫逃避機構を検出し、生体防御に働くように進化して病原微生物に対抗してきたことが考えられる。","subitem_description_type":"Abstract"},{"subitem_description":"In this study, a comprehensive search for interaction between pathogens and host immune receptors was performed. In this process, it was found that microbial pathogens have evolved to acquire antibody-cleaving proteases in order to escape from the host immune system of antibody recognition. Moreover, it was also found that an orphan activating immune receptor, LILRA2, recognizes these microbially disrupted antibody in order to counteract the microbial immune evasion strategy.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26870334, 研究期間(年度): 2014-04-01 – 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「細菌感染により壊れた抗体を認識する新規活性化レセプターの機能と多様性」研究成果報告書　課題番号26870334\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26870334/26870334seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学先進予防医学研究センター / 大阪大学","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00055324","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30585170"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30585170","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26870334/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26870334/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26870334/26870334seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26870334/26870334seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-09-05"}],"displaytype":"detail","filename":"FR-PR-HIRAYASU-K-kaken 2017-5p.pdf","filesize":[{"value":"500.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"FR-PR-HIRAYASU-K-kaken 2017-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/49009/files/FR-PR-HIRAYASU-K-kaken 2017-5p.pdf"},"version_id":"98e3c95c-d55c-414f-a278-1efe56503a1f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"細菌感染により壊れた抗体を認識する新規活性化レセプターの機能と多様性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"細菌感染により壊れた抗体を認識する新規活性化レセプターの機能と多様性"},{"subitem_title":"Functional and genetic diversity of the activating receptor to recognize microbially cleaved antibody","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-09-05"},"publish_date":"2019-09-05","publish_status":"0","recid":"49009","relation_version_is_last":true,"title":["細菌感染により壊れた抗体を認識する新規活性化レセプターの機能と多様性"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:13:48.354252+00:00"}