{"created":"2023-07-27T06:53:56.862924+00:00","id":49010,"links":{},"metadata":{"_buckets":{"deposit":"f8f0228c-621e-4b8c-bfdb-4f8fd95fe96c"},"_deposit":{"created_by":18,"id":"49010","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"49010"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00049010","sets":["2812:2813:2821"]},"author_link":["87685","87686"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-29","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2011 – 2012","bibliographic_titles":[{"bibliographic_title":"平成24(2012)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"未だに感染症は人類にとって脅威でありながら、病原体の感染メカニズムや感染症の重症化要因についてはほとんどわかっていない。病原体と相互作用を示す分子の遺伝子は、遺伝子欠損などの特徴的な遺伝子配列を示す場合がある。そこで本研究では、機能未知かつ特徴的な遺伝子配列を示す分子は病原体と相互作用する可能性は高いと考え、様々な病原体と宿主分子との相互作用を網羅的に調べた。その過程において、特定の活性化レセプターが細菌感染によって分解された宿主タンパク質を認識する事が明らかとなった。この結果は、活性化レセプターによって細菌の侵入を感知する宿主の新たな生体防御機構が存在することを示唆している。","subitem_description_type":"Abstract"},{"subitem_description":"Infectious diseases are still threats to humans, and the mechanism by which pathogens infect their hosts is not fully understood yet. The present study tested the hypothesis that molecules carrying mutations with unknown function interact with pathogens. In the process of comprehensive search for interaction between pathogens and host molecules, it was found that an orphan activating receptor specifically recognized some host molecule degraded by bacteria. These results suggest that host immune system has a novel strategy to sense bacterial invasion via an activating receptor.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23790385, 研究期間(年度):2011 – 2012","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「自然選択の影響を受けた遺伝子に着目した病原体と宿主との相互作用の解明」課題番号23790385\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23790385/23790385seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00055325","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学先進予防医学研究センター / 大阪大学"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30585170"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30585170","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790385/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790385/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23790385/23790385seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23790385/23790385seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-09-05"}],"displaytype":"detail","filename":"FR-PR-HIRAYASU-K-kaken 2014-4p.pdf","filesize":[{"value":"412.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"FR-PR-HIRAYASU-K-kaken 2014-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/49010/files/FR-PR-HIRAYASU-K-kaken 2014-4p.pdf"},"version_id":"02bbb35a-7e85-4988-8799-98b354b5def6"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"自然選択の影響を受けた遺伝子に着目した病原体と宿主との相互作用の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"自然選択の影響を受けた遺伝子に着目した病原体と宿主との相互作用の解明"},{"subitem_title":"Interaction between pathogens and host genes undergoing natural selection","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2821"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-09-05"},"publish_date":"2019-09-05","publish_status":"0","recid":"49010","relation_version_is_last":true,"title":["自然選択の影響を受けた遺伝子に着目した病原体と宿主との相互作用の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:34:00.303517+00:00"}