{"created":"2023-07-27T06:53:57.039375+00:00","id":49017,"links":{},"metadata":{"_buckets":{"deposit":"552d9992-5d36-4310-9d3c-7f0ea758b20c"},"_deposit":{"created_by":18,"id":"49017","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"49017"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00049017","sets":["2812:2813:2818"]},"author_link":["2883","87697"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06-10","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2014-04-01 – 2016-03-31","bibliographic_titles":[{"bibliographic_title":"平成27(2015)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書"},{"bibliographic_title":"2015 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Inoue, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"87697","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50397832","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50397832"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"摂食に伴い増加するインスリンや様々な栄養素が、中枢神経に作用し、迷走神経・クッパー細胞を介して、肝臓IL-6/STAT3シグナルを活性化することを見出している。一方で、転写因子STAT3は、抗アポトーシスおよび細胞増殖関連遺伝子の発現誘導を介し、肝再生のマスターレギュレーターとして重要な働きを担っている。本研究において、中枢神経による迷走神経制御と肝臓STAT3活性化の仕組みを明らかにするとともに、その仕組みがインスリン抵抗性・肥満状態では障害されることを見出している。肥満・インスリン抵抗性による中枢神経性肝臓機能調節の異常が、肝再生障害と相関する可能性を示唆するものである。","subitem_description_type":"Abstract"},{"subitem_description":"Brain-mediated hepatic responses, including gluconeogenic suppression, are mediated by the vagus nerve and hepatic IL-6/STAT3 activation. Meanwhile, hepatic STAT3 is known as the master regulator of hepatic regeneration, controlling the expressions of anti-apoptotic genes and cell-cycle related genes. In this project, we elucidate the mechanism of how brain regulates the vagus nerve and hepatic STAT3 activation. Further, we have found that the central-mediated hepatic responses are impeded in obesity. While hepatic regeneration is impaired in insulin-resistance and obesity, the impeded brain-mediated hepatic responses may be related to the obesity-induced dysfunction of hepatic regeneration.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26670599, 研究期間(年度):2014-04-01 – 2016-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「NAFLDでの肝切除後肝再生障害における中枢神経性肝臓機能調節の有用性の解明」課題番号:26670599\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26670599/26670599seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学新学術創成研究機構","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00055332","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50397832"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50397832","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26670599/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26670599/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26670599/26670599seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26670599/26670599seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"井上, 啓"}],"nameIdentifiers":[{"nameIdentifier":"2883","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50397832","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50397832"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-09-05"}],"displaytype":"detail","filename":"FR-PR-INOUE-H-kaken 2016-4p.pdf","filesize":[{"value":"81.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"FR-PR-INOUE-H-kaken 2016-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/49017/files/FR-PR-INOUE-H-kaken 2016-4p.pdf"},"version_id":"14ece7fe-4bfe-4525-aca9-2cf5e6bf30af"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"NAFLDでの肝切除後肝再生障害における中枢神経性肝臓機能調節の有用性の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"NAFLDでの肝切除後肝再生障害における中枢神経性肝臓機能調節の有用性の解明"},{"subitem_title":"The role of central-mediated hepatic responses in the obesity-induced impediment of hepatic regeneration","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-09-05"},"publish_date":"2019-09-05","publish_status":"0","recid":"49017","relation_version_is_last":true,"title":["NAFLDでの肝切除後肝再生障害における中枢神経性肝臓機能調節の有用性の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:41:29.626699+00:00"}