{"created":"2023-07-27T06:53:57.083416+00:00","id":49018,"links":{},"metadata":{"_buckets":{"deposit":"03fa6db1-b70a-4ca7-afd2-a36972725e3d"},"_deposit":{"created_by":18,"id":"49018","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"49018"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00049018","sets":["2812:2813:2817"]},"author_link":["2883","87697"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-06-03","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2014-04-01 – 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"代表者らは、ヒスチジンが中枢神経ヒスタミン作用に依存して肝糖産生を抑制し、血糖減少作用を発揮する事を見出している。ヒスチジンの耐糖能異常改善食材としての有用性が期待されるが、中枢神経ヒスチジン作用の肝臓での分子メカニズムは明らかではない。本研究では、中枢神経ヒスチジン作用は、迷走神経を介し、肝臓STAT3シグナルを活性化し、肝糖新生系酵素の遺伝子発現を抑制することを明らかにした。迷走神経は、クッパー細胞α7型ニコチン性アセチルコリン受容体を介して、肝臓STAT3シグナルを抑制しており、中枢神経ヒスチジン作用が、迷走神経活動を抑制することにより、肝臓STAT3シグナルを活性化することを見出した。","subitem_description_type":"Abstract"},{"subitem_description":"We have reported that histidine administration reduced blood glucose levels in mice, by suppressing hepatic glucose production via central histamine action. Although histidine is expected to be a candidate for blood glucose-lowering nutrient, the precise mechanism of how central histidine suppresses hepatic glucose production remains unclear. Here, we found that central action of histidine and histamine decreased hepatic gluconeogenic genes by activating hepatic STAT3 signaling via the vagus nerve. Moreover, we found that the vagus nerve suppressed hepatic IL-6/STAT3 signaling via the α7-nicotinic acetylcholine receptors, and that central insulin action activated hepatic IL-6/STAT3 signaling by suppressing vagal activity.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26282022, 研究期間(年度):2014-04-01 – 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「生活習慣病予防におけるアミノ酸の中枢性肝糖産生抑制作用の有用性の解明」研究成果報告書　課題番号26282022\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26282022/26282022seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学新学術創成研究機構","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00055333","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50397832"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50397832","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26282022/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26282022/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26282022/26282022seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26282022/26282022seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-09-05"}],"displaytype":"detail","filename":"FR-PR-INOUE-H-kaken 2017-5p.pdf","filesize":[{"value":"91.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"FR-PR-INOUE-H-kaken 2017-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/49018/files/FR-PR-INOUE-H-kaken 2017-5p.pdf"},"version_id":"e7562e6e-06ca-477b-bedd-439f9d487a50"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"生活習慣病予防におけるアミノ酸の中枢性肝糖産生抑制作用の有用性の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"生活習慣病予防におけるアミノ酸の中枢性肝糖産生抑制作用の有用性の解明"},{"subitem_title":"Understanding the mechanism of how central action of amino acids suppresses hepatic glucose production","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-09-05"},"publish_date":"2019-09-05","publish_status":"0","recid":"49018","relation_version_is_last":true,"title":["生活習慣病予防におけるアミノ酸の中枢性肝糖産生抑制作用の有用性の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:13:50.321725+00:00"}