{"created":"2023-07-27T06:53:57.259917+00:00","id":49023,"links":{},"metadata":{"_buckets":{"deposit":"35a430a3-f810-4db6-85df-a845a2357067"},"_deposit":{"created_by":18,"id":"49023","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"49023"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00049023","sets":["2812:2813:2815"]},"author_link":["87703","2851"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-05-06","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2015-04-01 – 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 若手研究(A) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Inaba, Yuka"}],"nameIdentifiers":[{"nameIdentifier":"87703","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20571970","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20571970"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"肝臓の持つ強靭な再生能は、脂肪肝では障害され、肝切除術後の肝不全など合併症を引き起こす。脂肪肝での再生障害の危険性が広く知られる一方で、その病因・治療法は、十分に解明されていなかった。代表者は、脂肪肝での再生障害に、多様な細胞内ストレスに共通して誘導される「統合的ストレス応答」が、主要な役割を果たす事を見出している。本研究では、脂肪肝再生障害メカニズムとして、ストレス誘導性転写因子ATF3が重要な役割を担うことを明らかにした。","subitem_description_type":"Abstract"},{"subitem_description":"The liver has robust regenerative potential in response to damage, but hepatic steatosis weakens this potential. That is known the impaired liver regeneration causes complications after surgery, such as liver failure. However the detail of mechanisms was unclear. The enhanced integrated stress response (ISR) is commonly induced by various cellular stress. We found that ISR plays a key role in impaired regeneration of hepatic steatosis. In this study, we revealed that stress induced transcription factor has an important role as the mechanism of liver regeneration disorder in fatty liver disease.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15H05678, 研究期間(年度):2015-04-01 – 2019-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「統合的ストレス応答の制御によるNAFLDでの肝切除後肝再生障害の新規治療法の解明」課題番号15H05678\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15H05678/15H05678seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00055338","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学新学術創成研究機構"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20571970"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20571970","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H05678/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H05678/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15H05678/15H05678seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15H05678/15H05678seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"稲葉, 有香"}],"nameIdentifiers":[{"nameIdentifier":"2851","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20571970","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20571970"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-04-27"}],"displaytype":"detail","filename":"FR-PR-INABA-Y-kaken 2019-5p.pdf","filesize":[{"value":"408.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"FR-PR-INABA-Y-kaken 2019-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/49023/files/FR-PR-INABA-Y-kaken 2019-5p.pdf"},"version_id":"567661e6-34ef-4ad4-83e9-cf3a74439a26"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"統合的ストレス応答の制御によるNAFLDでの肝切除後肝再生障害の新規治療法の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"統合的ストレス応答の制御によるNAFLDでの肝切除後肝再生障害の新規治療法の解明"},{"subitem_title":"Analysis of the effects by the regulation of integrative stress response to impaired liver regeneration in NAFLD","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-27"},"publish_date":"2020-04-27","publish_status":"0","recid":"49023","relation_version_is_last":true,"title":["統合的ストレス応答の制御によるNAFLDでの肝切除後肝再生障害の新規治療法の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:29:10.014707+00:00"}