{"created":"2023-07-27T06:54:02.727937+00:00","id":49163,"links":{},"metadata":{"_buckets":{"deposit":"49fe77e5-90e5-4940-9f2c-3036ef6caa02"},"_deposit":{"created_by":18,"id":"49163","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"49163"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00049163","sets":["2812:2813:2821"]},"author_link":["88076","440"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-05-31","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2011-2012","bibliographic_titles":[{"bibliographic_title":"平成24(2012)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2012 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"EGFRチロシンキナーゼ阻害薬(EGFR-TKI)に自然耐性を示すK-ras活性化変異を有する肺がんに対しては、未だ有効な分子標的薬はない。我々はβ-phenylthyl isothiocynate (PEITC)による活性酸素産生を介したK-ras 変異肺がん細胞に対する抗腫瘍効果について検討を行った。PEITCを添加するとK-ras変異肺がん細胞の生存率は低下し、アポトーシスが誘導された。マウス皮下移植モデルにおいては、PEITC投与によって著明な腫瘍縮小効果を認め、毒性はほとんど認めなかった。また、ヒト正常肺線維芽細胞やK-ras野生型の肺がん細胞はPEITCに対する感受性が低かった。以上の結果から、PEITCはK-ras変異肺がん細胞に選択的な殺細胞効果を有することが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"There are still no effective targeted therapies for patients with K-ras activating mutations which is a cause of intrinsic resistance to EGFR-TKI. Here, we assessed therapeutic effect of β-phenylthyl isothiocynate (PEITC) on lung cancer cellswith K-ras activating mutations through production of reactive oxygen species (ROS).Treatment with PEITC reduced cell viability and induced apoptosis in K-ras mutant lung cancer cells. In a xenograft model, PEITC dramatically reduced tumor growth with less toxicity. Moreover, normal human fibloblasts and K-ras wild lung cancer cells weresignificantly less sensitive to PEITC. Our findings suggest that PEITC can selectively kill lung cancer cells with K-ras activating mutations.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23790903, 研究期間(年度):2011-2012","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「Rasシグナル活性化変異を有する原発性肺癌を標的とした新規治療法の開発」課題番号23790903\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23790903/23790903seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00055476","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学附属病院がんセンター"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=90565384"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=90565384","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790903/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790903/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23790903/23790903seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23790903/23790903seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-09-20"}],"displaytype":"detail","filename":"CA-PR-TAKEUCHI-S-kaken 2013-4p.pdf","filesize":[{"value":"421.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-TAKEUCHI-S-kaken 2013-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/49163/files/CA-PR-TAKEUCHI-S-kaken 2013-4p.pdf"},"version_id":"a67c5fdb-e9c6-40af-afd6-c3360a0c2072"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"Rasシグナル活性化変異を有する原発性肺癌を標的とした新規治療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Rasシグナル活性化変異を有する原発性肺癌を標的とした新規治療法の開発"},{"subitem_title":"Development of novel targeted therapy for lung cancer with activating Ras mutation","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2821"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-09-20"},"publish_date":"2019-09-20","publish_status":"0","recid":"49163","relation_version_is_last":true,"title":["Rasシグナル活性化変異を有する原発性肺癌を標的とした新規治療法の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:34:01.906230+00:00"}