{"created":"2023-07-27T06:54:03.562056+00:00","id":49198,"links":{},"metadata":{"_buckets":{"deposit":"c76a14b9-1f5b-4d6c-9076-1de3d0512ecc"},"_deposit":{"created_by":18,"id":"49198","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"49198"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00049198","sets":["2812:2813:2823"]},"author_link":["85","85740"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-06-06","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"8p.","bibliographicVolumeNumber":"2008-2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"増殖因子が幹細胞を制御する分子機構や、増殖因子を介して各組織や臓器が発生する分子機構の解明を、新規バイオインフォマティクスを用いて目指した。研究代表者がこれまでに作製した増殖因子FGFの細胞内司令塔分子FRS2alphaの変異マウスの解析から、神経幹細胞の自己複製能の鍵分子Hes1、心臓の発生パスウエイの鍵としてFRS2alpha-Shp2-Tbx2が明らかになった。さらに、乳腺幹細胞並びに乳癌幹細胞の自己複製能の鍵分子、NFkBが明らかになった。","subitem_description_type":"Abstract"},{"subitem_description":"We aimed to clarify molecular mechanisms how growth factors regulate self-renewing activity of tissue type specific stem cells by using novel bioinfomatics. As a result, we identified Hes1 as a key molecular target of self-renewal of neural stem cells and FRS2alpha-Shp2-Tbx2 pathway as a key pathway for development of cardiac progenitor cells. Moreover, we identified NFkB as a key molecular target for self-renewing mammalian stem cells as well as breast cancer stem cells.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"出典：研究課題「増殖因子による幹細胞並びに個体発生の動態制御のシステム生物学的解析」課題番号20390075\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20390075/20390075seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所 / 東京大学医科学研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00055511","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=10251448"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=10251448","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390075/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390075/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20390075/20390075seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20390075/20390075seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-09-20"}],"displaytype":"detail","filename":"CA-PR-GOTO-N-kaken 2011-8p.pdf","filesize":[{"value":"557.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-GOTO-N-kaken 2011-8p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/49198/files/CA-PR-GOTO-N-kaken 2011-8p.pdf"},"version_id":"6eba4b66-94e5-4727-b9e2-0e43bd0a82ab"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"増殖因子による幹細胞並びに個体発生の動態制御のシステム生物学的解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"増殖因子による幹細胞並びに個体発生の動態制御のシステム生物学的解析"},{"subitem_title":"Systems biological analysis of dynamic regulation of stem cells and development by growth factors","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-09-20"},"publish_date":"2019-09-20","publish_status":"0","recid":"49198","relation_version_is_last":true,"title":["増殖因子による幹細胞並びに個体発生の動態制御のシステム生物学的解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:21:32.421768+00:00"}