{"created":"2023-07-27T06:54:03.739792+00:00","id":49205,"links":{},"metadata":{"_buckets":{"deposit":"f3820620-a8a1-453c-abe6-b01f44c7a652"},"_deposit":{"created_by":18,"id":"49205","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"49205"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00049205","sets":["2812:2813:2816"]},"author_link":["88136","88137"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-06-03","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2014-04-01 - 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究は、病原性細菌と宿主間の相互作用による病態形成機序の解明を目的とし、リステリア感染および肺炎球菌感染おける自然機構インフラマソームの役割を検討した。インフラマソームを構成するASCが致死性リステリア感染モデルにおいてIL-18依存的に感染を増悪化させることを発見し、その機序を明らかにした。また、肺炎球菌肺炎において、ASCがインフラマソーム非依存的にSTAT6活性化を持続させることで粘膜防御因子の発現低下を抑制し、宿主防御に寄与することを見出した。さらに、肺炎球菌がpneumolysinを産生することで肺炎増悪化因子IL-1αの産生をインフラマソーム非依存的に誘導することを報告した。","subitem_description_type":"Abstract"},{"subitem_description":"The aim of this study is to elucidate the roles for inflammasomes in infection with L. monocytogenes and S. pneumoniae, for the purpose of understanding pathological mechanism mediated by host-pathogen interactions. We found that the inflammasome adaptor ASC exacerbates lethal listeriosis by mediating IL-18 production, which leads to NK cell-dependent production of the immunosuppressive cytokine IL-10. It was also found that during pneumococcal pneumoniae, ASC sustains STAT6 activation in airway epithelial cells in an inflammasome-independent manner, thereby inhibiting the down-regulation of mucosal defense genes contributing to host defense against the pathogen. In addition, we reported that pneumolysin, a virulence factor of S. pneumoniae, plays a critical role in the production of IL-1α, which has been demonstrated as a mediator of lung inflammation, in response to this bacterium. The IL-1α production was dependent on calcium ions influx and calpain, but not the inflammasome.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26460523, 研究期間(年度):2014-04-01 - 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「インフラマソーム構成タンパクを介した新たな感染防御機構の発見およびその機序の解明」課題番号26460523\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26460523/26460523seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00055518","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50437216"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50437216","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26460523/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26460523/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26460523/26460523seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26460523/26460523seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-09-20"}],"displaytype":"detail","filename":"CA-PR-TSUCHIYA-K-kaken 2018-6p.pdf","filesize":[{"value":"332.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-TSUCHIYA-K-kaken 2018-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/49205/files/CA-PR-TSUCHIYA-K-kaken 2018-6p.pdf"},"version_id":"6c966820-5f0c-485e-b8ef-004dd4afc601"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"インフラマソーム構成タンパクを介した新たな感染防御機構の発見およびその機序の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"インフラマソーム構成タンパクを介した新たな感染防御機構の発見およびその機序の解明"},{"subitem_title":"Caspase-1-independent roles for inflammasome-forming proteins in bacterial infections","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-09-20"},"publish_date":"2019-09-20","publish_status":"0","recid":"49205","relation_version_is_last":true,"title":["インフラマソーム構成タンパクを介した新たな感染防御機構の発見およびその機序の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:49:25.019040+00:00"}