{"created":"2023-07-27T06:54:03.964806+00:00","id":49212,"links":{},"metadata":{"_buckets":{"deposit":"a0bd1e71-8204-4e05-85c0-b50db26f7803"},"_deposit":{"created_by":18,"id":"49212","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"49212"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00049212","sets":["2812:2813:2816"]},"author_link":["88146","88144"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-25","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2016-08-26 - 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 研究活動スタート支援 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"HGF-MET経路の無秩序な活性化は、薬剤耐性や転移性等の悪性形質の獲得に寄与することが報告されている。本課題では、活性型HGFおよびMETに対し極めて高い選択親和性を持つ特殊環状ペプチドを、PETプローブとして応用することで、HGF-MET経路のin vivo活性化イメージングを試みた。\nCu-64標識抗HGFペプチドを用いたイメージングの結果、HGF強制発現細胞を担がんしたヒト化マウスモデルにおいて、HGFの発現に依存したペプチドの集積が確認された。さらに抗METペプチドと培養細胞を用いた検討から、ペプチドのKd値・pI値等の化学的物性と取り込み効率の間に相関があることを見出した。","subitem_description_type":"Abstract"},{"subitem_description":"Activation of HGF-MET signaling causes resistance to molecular targeted drugs. Biomarkers that reflect expression levels and activation status for HGF-MET pathway are potentially be useful for diagnosis and better treatment of patients. In this study, we attempted to visualize for HGF-MET activation state with the PET imaging by using cyclic peptides which specifically bind to HGF or MET. In PET analysis, Cu-64-labeled HGF binder accumulated in HGF-overexpressing cancer xenografts at higher levels than those in parental xenografts in humanized mouse model. In MET-binding cyclic peptides, we evaluated cellular accumulation of MET probes following MET activation in relation to their chemical properties. Therefore, our results suggest that the novel imaging probes may become valuable companion diagnostic tools to evaluate activation status of HGF-MET pathway for patient selection for drug development and treatment.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16H06830, 研究期間(年度):2016-08-26 - 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「特殊環状ペプチドをイメージングツールとするがん微小転移および薬剤耐性に関する研究」課題番号16H06830\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16H06830/16H06830seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学新学術創成研究機構ナノ生命科学研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00055525","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20781173"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20781173","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H06830/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H06830/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16H06830/16H06830seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16H06830/16H06830seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-09-20"}],"displaytype":"detail","filename":"CA-PR-SATO-H-kaken 2018-4p.pdf","filesize":[{"value":"389.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-SATO-H-kaken 2018-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/49212/files/CA-PR-SATO-H-kaken 2018-4p.pdf"},"version_id":"a6c52f3b-69c1-4898-82cf-6ffb0b6d77bc"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"特殊環状ペプチドをイメージングツールとするがん微小転移および薬剤耐性に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"特殊環状ペプチドをイメージングツールとするがん微小転移および薬剤耐性に関する研究"},{"subitem_title":"Studies of drug resistance and micro-metastasis using macrocyclic peptides as molecular imaging probes","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-09-20"},"publish_date":"2019-09-20","publish_status":"0","recid":"49212","relation_version_is_last":true,"title":["特殊環状ペプチドをイメージングツールとするがん微小転移および薬剤耐性に関する研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:49:27.909086+00:00"}