{"created":"2023-07-27T06:54:04.009474+00:00","id":49214,"links":{},"metadata":{"_buckets":{"deposit":"8b8d053f-9af9-4190-8a42-4d34474f9973"},"_deposit":{"created_by":18,"id":"49214","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"49214"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00049214","sets":["2812:2813:2815"]},"author_link":["88150","2674"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-05-21","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2016-04-01 - 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"JSAPはモータータンパク質と積荷をつなぐアダプター分子として機能することが知られている。神経細胞でのJSAP機能喪失により活性化するJNK（細胞内情報伝達分子の１つ）は、軸索内で逆行性に輸送され、その結果、神経細胞死が誘導されることを明らかにした。また、分裂細胞において、JSAP発現亢進・機能喪失がもたらす染色体分配異常は、細胞内輸送制御の破綻に起因する可能性を見出した。 ","subitem_description_type":"Abstract"},{"subitem_description":"JSAP is known to function as an adaptor protein linking cargoes to kinesin/dynein motor proteins. We found that activated axonal JNK moves retrogradely in a dynein-dependent manner in JSAP-deficient neurons, and induces neuronal death. We also suggest that JSAP plays an important role in the regulation of intracellular transport system, and that its impairment by increased expression of JSAP or JSAP loss-of-function is likely to be causative for chromosome segregation errors in dividing cells. ","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16K08579, 研究期間(年度):2016-04-01 - 2019-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「JSAPによる細胞内輸送制御の破綻に起因する神経細胞死と染色体分配異常の分子機構」課題番号16K08579\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K08579/16K08579seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00055527","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学がん進展制御研究所"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=60200937"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=60200937","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K08579/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K08579/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K08579/16K08579seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K08579/16K08579seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-05-14"}],"displaytype":"detail","filename":"CA-PR-YOSHIOKA-K-kaken 2019-4p.pdf","filesize":[{"value":"716.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-YOSHIOKA-K-kaken 2019-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/49214/files/CA-PR-YOSHIOKA-K-kaken 2019-4p.pdf"},"version_id":"4759b3cf-94d0-4995-900d-ee3b42479b58"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"JSAPによる細胞内輸送制御の破綻に起因する神経細胞死と染色体分配異常の分子機構","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"JSAPによる細胞内輸送制御の破綻に起因する神経細胞死と染色体分配異常の分子機構"},{"subitem_title":"Molecular mechanisms of neuronal cell death and chromosome segregation errors induced by defects in JSAP-mediated intracellular transport","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-05-14"},"publish_date":"2020-05-14","publish_status":"0","recid":"49214","relation_version_is_last":true,"title":["JSAPによる細胞内輸送制御の破綻に起因する神経細胞死と染色体分配異常の分子機構"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:32:35.104219+00:00"}