{"created":"2023-07-27T06:54:14.836700+00:00","id":49427,"links":{},"metadata":{"_buckets":{"deposit":"7d1d22cd-0753-4601-bde2-73b866358165"},"_deposit":{"created_by":18,"id":"49427","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"49427"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00049427","sets":["2812:2813:2815"]},"author_link":["1827","69899"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-05-10","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2016-04-01 - 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では　Na+/H+交換輸送体(NHE)のうちNHE5の大腸癌における意義を解析しNHE5特異的阻害剤による新規抗がん治療法を開発する事を目的とした。癌組織では細胞外が酸性で細胞内がアルカリであり細胞内H+を細胞外に排出にNHEが深く関与している。NHE5は大腸癌組織において高頻度で過剰発現が確認され、NHE5が癌細胞における細胞外およびエンドゾーム内の弱酸性化環境形成に伴う癌細胞の細胞増殖能・浸潤能・転移能の獲得に重要な役割を果たしている可能性がある。NHE1阻害剤をリード化合物としてNHE5選択的阻害剤を分子設計合成し、NHE5活性の阻害効果と細胞増殖抑制効果を検討した。 ","subitem_description_type":"Abstract"},{"subitem_description":"Malignant tumors have an acidic extracellular pH and alkaline intracellular pH, which is facilitated by altered metabolism of tumor cells and the hypoxic tumor microenvironment. Na+/H+ exchangers (NHEs) play important roles in secreting protons in tumor cells. Neuron enriched NHE5 dynamically shuttles between the plasma membrane and recycling endosomes, serving as a mechanism that regulates pH across the endosomal and plasma membranes. NHE5 plays an important role in endocytic recycling of tyrosine kinase receptor. In this study, we try to establish a new therapeutic strategy for colon cancer.by synthesizing novel NHE5 specific inhibitor. ","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16K10530, 研究期間(年度):2016-04-01 - 2019-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「大腸癌における Na+/H+交換輸送体阻害による新規抗癌治療法の開発」課題番号16K10530\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K10530/16K10530seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00055739","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学附属病院光学医療診療部"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=60345618"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=60345618","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K10530/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K10530/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K10530/16K10530seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K10530/16K10530seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-05-14"}],"displaytype":"detail","filename":"HO-PR-NINOMIYA-I-kaken 2019-5p.pdf","filesize":[{"value":"270.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-NINOMIYA-I-kaken 2019-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/49427/files/HO-PR-NINOMIYA-I-kaken 2019-5p.pdf"},"version_id":"a363b4be-b4e8-469c-b181-8fe92a0c786d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"大腸癌における Na+/H+交換輸送体阻害による新規抗癌治療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"大腸癌における Na+/H+交換輸送体阻害による新規抗癌治療法の開発"},{"subitem_title":"Development of novel colon cancer treatment by Na+/H+ exchanger inhibitor","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-05-14"},"publish_date":"2020-05-14","publish_status":"0","recid":"49427","relation_version_is_last":true,"title":["大腸癌における Na+/H+交換輸送体阻害による新規抗癌治療法の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:32:33.475550+00:00"}