{"created":"2023-07-27T06:54:14.882955+00:00","id":49429,"links":{},"metadata":{"_buckets":{"deposit":"02b25e30-5257-4229-a311-1b9f234a66e2"},"_deposit":{"created_by":18,"id":"49429","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"49429"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00049429","sets":["2812:2813:2815"]},"author_link":["69904","373"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-06-17","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2016-04-01 - 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"胃食道逆流症（GERD）による慢性炎症により制御性T細胞やM2型マクロファージといった抑制性免疫細胞が誘導され、これらの細胞によってTGF-βやIL-10といった免疫抑制性サイトカインが産生されることにより癌の微小環境が構築されると考えられた。またメトホルミン投与によりこれらのサイトカイン産生能が低下し、pSTAT3の発現も低下していた。さらに発癌率を低下させることが確認された。\nエピゲノム解析により、DNAメチル化酵素をコードする遺伝子の一つであるDnmt3aが低下し、ヒストン脱アセチル化酵素をコードする遺伝子の一つであるHdac9が低下していることが示された。 ","subitem_description_type":"Abstract"},{"subitem_description":"Recently, metformin has been reported to be an anti-inflammatory, inhibition of phospho-Stat3 and antitumor activity. We evaluated that the dynamic alterations of infiltrating immune cells in esophageal carcinogenesis and investigated the anti-cancer effects of metformin.\nFlow cytometric analysis demonstrated that the balance of M1- and M2-polarized macrophages, as well as the number of phospho-Stat3-positive macrophages, regulatory T cells, cytotoxic T cells, and natural killer cells, were dynamically changed at each stage of the disease. Metformin treatment stimulated immunomodulation at every stage. Overall, these findings suggest that metformin suppressed the esophageal carcinogenesis by improving the immunosuppressive tumor microenvironment.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16K10493, 研究期間(年度):2016-04-01 - 2019-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「逆流性食道炎による食道発癌過程でのエピゲノム変化とがん微小環境の解明とその制御」課題番号16K10493\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K10493/16K10493seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00055741","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30397210"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30397210","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K10493/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K10493/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K10493/16K10493seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K10493/16K10493seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-05-14"}],"displaytype":"detail","filename":"HO-PR-MIYASHITA-T-kaken 2019-4p.pdf","filesize":[{"value":"71.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-MIYASHITA-T-kaken 2019-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/49429/files/HO-PR-MIYASHITA-T-kaken 2019-4p.pdf"},"version_id":"9c49211f-11d3-430f-9c69-01b5fb1a858c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"逆流性食道炎による食道発癌過程でのエピゲノム変化とがん微小環境の解明とその制御","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"逆流性食道炎による食道発癌過程でのエピゲノム変化とがん微小環境の解明とその制御"},{"subitem_title":"Antitumor Effects of Metformin Due to Regulation of the Immunosuppressive Tumor Microenvironment","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-05-14"},"publish_date":"2020-05-14","publish_status":"0","recid":"49429","relation_version_is_last":true,"title":["逆流性食道炎による食道発癌過程でのエピゲノム変化とがん微小環境の解明とその制御"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:32:32.014765+00:00"}