{"created":"2023-07-27T06:54:15.206214+00:00","id":49458,"links":{},"metadata":{"_buckets":{"deposit":"953bac0e-b10e-4692-9408-8220f320c5a9"},"_deposit":{"created_by":18,"id":"49458","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"49458"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00049458","sets":["2812:2813:2817"]},"author_link":["88919","2256"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-06-06","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2015-04-01 - 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"膠芽腫は予後不良な悪性腫瘍であり、膠芽腫幹細胞に対する治療が再発予防や根治性の向上に重要とされている。我々は、Notch阻害薬はAktシグナル抑制によって膠芽腫幹細胞へ効果を示すことと高感受性群と低感受性群に分けられることを報告した。本研究では、Notch阻害剤低感受性膠芽腫幹細胞群に対しNotch阻害剤とAkt阻害剤の併用療法の有効性を評価した。2剤併用療法は単剤よりも有意に細胞増殖抑制、幹細胞形質維持の抑制、アポトーシス誘導の増強を認めた。したがってNotch阻害薬にAkt阻害薬を併用することによりNotch阻害剤低感受性膠芽腫幹細胞を制御できることは示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Glioblastoma is the most malignant primary brain tumor in humans. The patinets with glioblastoma have a uniformly poor prognosis. The significance of targeting glioblastoma-stem cells may be important for successful treatment. In this study, we analyzed the efficacy of the Nothc inhibitor and Akt inhibitor for glioblastoma stem cell with Notch inhibitor resistance. Notch inhibitor concomitant Akt inhibitor treatment enhanced the effect by monothearapy such as suppression of cell proliferation and stemness maintenance, and promotion of apoptosis.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K19956, 研究期間(年度):2015-04-01 - 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「Notch, Aktシグナル阻害によるグリオーマ幹細胞の完全制御」研究成果報告書　課題番号15K19956\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K19956/15K19956seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00055770","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=40507084"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=40507084","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K19956/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K19956/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K19956/15K19956seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K19956/15K19956seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-10-11"}],"displaytype":"detail","filename":"ME-PR-TANAKA-S-kaken 2017-5p.pdf","filesize":[{"value":"752.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-TANAKA-S-kaken 2017-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/49458/files/ME-PR-TANAKA-S-kaken 2017-5p.pdf"},"version_id":"1f0e0f89-d138-4fa2-9daf-ab3dbad15e35"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"Notch, Aktシグナル阻害によるグリオーマ幹細胞の完全制御","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Notch, Aktシグナル阻害によるグリオーマ幹細胞の完全制御"},{"subitem_title":"Complete regulation of glioma stem cell by notch and Akt signal inhibition","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-10-11"},"publish_date":"2019-10-11","publish_status":"0","recid":"49458","relation_version_is_last":true,"title":["Notch, Aktシグナル阻害によるグリオーマ幹細胞の完全制御"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:14:02.177617+00:00"}