{"created":"2023-07-27T06:54:15.345385+00:00","id":49465,"links":{},"metadata":{"_buckets":{"deposit":"cda6cce3-1a46-43c7-98df-08aec52ab4d2"},"_deposit":{"created_by":18,"id":"49465","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"49465"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00049465","sets":["2812:2813:2815"]},"author_link":["88929","88928"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-06-19","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2016-04-01 - 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"上咽頭癌組織と細胞株でHERVの発現を認めたため、HERVがRE-1 likeモチーフを多く含むことから転写抑制因子であるRE1-silencing transcription factor (REST/NRSF)の発現に着目して研究を行った。RESTを強制発現させると癌幹細胞の表現型で見られるようにCD24の発現が抑制され、さらにマトリゲルを通過する細胞の数が増えた。以上のことから、RESTは転写抑制因子として上咽頭癌細胞のCICに関わっており、上咽頭癌の浸潤能に寄与することが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"In the present study we showed a panel of LMP1 expressing cell lines had high expression of REST compared with not. The enhancement of REST by LMP1 was regulated by activation of REST promoter, not blockade of ubiquitin-proteasome pathway. Furthermore, we demonstrated that REST works as transcriptional suppressor of CSC marker in NPC cells. Moreover, it enhances invasive potential of NPC cells. The series of findings indicate that REST functions as transcriptional repressor and involved with invasive potential of NPC expressing EBV oncogene.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16K20235, 研究期間(年度):2016-04-01 - 2019-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「上咽頭癌のリンパ球浸潤におけるヒト内在性レトロウイルスの関与」課題番号16K20235\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K20235/16K20235seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00055777","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学附属病院耳鼻咽喉科・頭頸部外科"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=90756230"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=90756230","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K20235/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K20235/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K20235/16K20235seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K20235/16K20235seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-05-15"}],"displaytype":"detail","filename":"ME-PR-AGA-M-kaken 2019-4p.pdf","filesize":[{"value":"73.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-AGA-M-kaken 2019-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/49465/files/ME-PR-AGA-M-kaken 2019-4p.pdf"},"version_id":"0657bdd3-4d93-4b29-9a41-78a5f1b3b8d2"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"上咽頭癌のリンパ球浸潤におけるヒト内在性レトロウイルスの関与","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"上咽頭癌のリンパ球浸潤におけるヒト内在性レトロウイルスの関与"},{"subitem_title":"The involvment of HERV in lymphocyte infitration of nasopharyngeal carcinoma","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-05-15"},"publish_date":"2020-05-15","publish_status":"0","recid":"49465","relation_version_is_last":true,"title":["上咽頭癌のリンパ球浸潤におけるヒト内在性レトロウイルスの関与"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:32:24.114927+00:00"}