{"created":"2023-07-27T06:54:15.711262+00:00","id":49477,"links":{},"metadata":{"_buckets":{"deposit":"2e6073b0-fc12-41b7-b756-14c7137e39b0"},"_deposit":{"created_by":18,"id":"49477","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"49477"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00049477","sets":["2812:2813:2822"]},"author_link":["88972","88973"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05-15","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2009-2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ATBF1(AT-motif binding factor 1)はα-fetoproteinの転写制御因子として発見されたが、その後、神経や筋の分化制御に関わったり、種々の癌で癌抑制遺伝としての働きがある。骨軟部腫瘍を中心にATBF1の発現や働きを解析しようと試みた。その結果、良性、低悪性度の骨軟部腫瘍群では免疫組織学的に核陽性を示す症例が多かったのに対して、高悪性度群では核に陽性を示す症例は少なかった。核陰性群は核陽性群に比し、悪性度が高く、癌細胞の悪性度診断を早期に行うことができる可能性を示唆している。","subitem_description_type":"Abstract"},{"subitem_description":"ATBF1(AT-motif binding factor 1) was discovered as a transcriptional regulator of α-fetoprotein. Thereafter, ATBF1 had a regulatory mechanism of a neuronal and skeletal muscular differentiation, and was a homeotic transcriptional regulatory factor identified as a tumor suppressor gene. We analyzed an immunohistochemical expression and function of ATBF1 on bone and soft tissue tumors. As a result, nuclear staining was observed in most cases of benign or low grade malignant tumor groups, however, in high grade malignant tumor group, one case showed nuclear positivity. Comparing nuclear staining negative group with nuclear staining positive group, we can imply that ATBF1 expression may have potential as a prognostic indicator for bone and soft tissue tumors.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"出典：研究課題「骨軟部腫瘍におけるATBF1遺伝子解析による悪性度評価の研究」課題番号21590389\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21590389/21590389seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院整形外科 / 金沢医科大学","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00055789","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50142732"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50142732","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590389/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590389/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21590389/21590389seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21590389/21590389seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-10-17"}],"displaytype":"detail","filename":"HO-PR-NOJIMA-T-kaken 2012-4p.pdf","filesize":[{"value":"301.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-NOJIMA-T-kaken 2012-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/49477/files/HO-PR-NOJIMA-T-kaken 2012-4p.pdf"},"version_id":"1dbe13f0-e590-43e7-9675-c21cd6cb331c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"骨軟部腫瘍におけるATBF1遺伝子解析による悪性度評価の研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"骨軟部腫瘍におけるATBF1遺伝子解析による悪性度評価の研究"},{"subitem_title":"A study of histological grading on bone and soft tissue tumors by analysis of ATBF1","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-10-17"},"publish_date":"2019-10-17","publish_status":"0","recid":"49477","relation_version_is_last":true,"title":["骨軟部腫瘍におけるATBF1遺伝子解析による悪性度評価の研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:24:32.990305+00:00"}