{"created":"2023-07-27T06:54:17.167710+00:00","id":49538,"links":{},"metadata":{"_buckets":{"deposit":"7b0d220f-fa0e-4971-ba73-e7bdadec57c5"},"_deposit":{"created_by":18,"id":"49538","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"49538"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00049538","sets":["2812:2813:2815"]},"author_link":["89059","89058"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-05-30","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2017-04-01 - 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"膠原病では抗核抗体および疾患特異的自己抗体が高率に検出される。それぞれの自己抗体は臨床的特徴を有している。我々は免疫沈降法による自己抗体のスクリーニングにて160kDa蛋白に対する新規自己抗体を検出した。MS解析にて抗原蛋白はscaffold attachment factor Bと判明した。抗SAFB抗体は全身性強皮症や多発性筋炎、皮膚筋炎、間質性肺疾患の患者で認められ、レイノー現象や爪上皮出血点を有していた。抗SAFB抗体は間質性肺疾患に関連した新規膠原病自己抗体であると考えた。","subitem_description_type":"Abstract"},{"subitem_description":"Antinuclear antibodies (ANAs) are a hallmark of autoimmune connective tissue diseases(CTD).The CTD-related autoAbs are associated with specific clinical features.During the screening process using immunoprecipitation assays in sera, we found several sera that occasionally reacted with a protein with a molecular weight of 160 kDa. Using a series of biochemical and molecular analyses, the autoantigen targeted by this Ab specificity was identified as scaffold attachment factor B (SAFB).The anti-SAFB Ab was detected in a small number of patients with systemic sclerosis,　polymyositis/dermatomyositis and interstitial lung disease (ILD).Patients with anti-SAFB Ab had Raynaud’s phenomenon and nail fold punctate hemorrhage.Anti-SAFB Ab is a novel CTD-related autoAb possibly associated with ILD.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:17K16331, 研究期間(年度):2017-04-01 - 2019-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「膠原病で検出された160kDaタンパクに対する自己抗体の抗原解析」課題番号17K16331\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K16331/17K16331seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00055850","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学附属病院皮膚科"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30746384"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30746384","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K16331/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K16331/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K16331/17K16331seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K16331/17K16331seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-05-15"}],"displaytype":"detail","filename":"ME-PR-FUJIKI-A-kaken 2019-4p.pdf","filesize":[{"value":"368.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-FUJIKI-A-kaken 2019-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/49538/files/ME-PR-FUJIKI-A-kaken 2019-4p.pdf"},"version_id":"d1e20f43-e1b5-4ea2-b7a6-c0c0e38aad28"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"膠原病で検出された160kDaタンパクに対する自己抗体の抗原解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"膠原病で検出された160kDaタンパクに対する自己抗体の抗原解析"},{"subitem_title":"The analysis of the autoantigen targeted by the autoantibody to a protein with a molecular weight of 160 kDa in sera with connective tissue disease","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-05-15"},"publish_date":"2020-05-15","publish_status":"0","recid":"49538","relation_version_is_last":true,"title":["膠原病で検出された160kDaタンパクに対する自己抗体の抗原解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:31:48.724883+00:00"}