{"created":"2023-07-27T06:54:17.213188+00:00","id":49543,"links":{},"metadata":{"_buckets":{"deposit":"9624096e-406d-41ef-9961-d603339fab55"},"_deposit":{"created_by":18,"id":"49543","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"49543"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00049543","sets":["2812:2813:2816"]},"author_link":["89068","89067"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-15","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2015-04-01 - 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"肝幹細胞の形質を有し、予後不良なEpCAM陽性肝細胞癌ではダイナミックCT動脈相における不均一な濃染パターン、内部の造影不染域含有、MRIの拡散強調像におけるより低値なADC値、Gd-EOB-DTPA造影MRI(EOB-MRI)肝細胞相におけるnon-smooth marginという画像特徴をEpCAM陰性肝細胞癌群に比較して有意に高い頻度で認められた。これらの画像所見はEpCAM陽性肝細胞癌を推察するのに有用であり、将来的な個別化医療に貢献するものと考えられる。一方、EMT関連HCCを画像で推察することは難しいと考えられたが、EOB-MRIの肝細胞相での増強率がより低値を示す傾向を示した。","subitem_description_type":"Abstract"},{"subitem_description":"Epithelial cell adhesion molecule (EpCAM) positive hepatocellular carcinomas (HCC) having hepatic stem cell feature showed significantly higher incidence of imaging features including a heterogeneous arterial enhancement and internal no enhancement portion on dynamic CT study, lower apparent diffusion coefficient (ADC) value on diffusion weighted image, and non-smooth margin on hepatobiliary phase (HB phse) of Gd-EOB-DTPA enhanced MRI (EOB-MRI). These imaging findings are useful for predicting EpCAM positive hepatocellular carcinoma and are thought to contribute to future personalized medicine.\nRegarding epithelial-mesenchymal transition (EMT) positive HCCs, there was no significant imaging features that can predict epithelial-mesenchymal transition (EMT) positive HCCs. However enhancement ratio of HB phase of EOB-MRI tended to be lower in EMT positive HCCs compared with EMT negative HCCs.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K19780, 研究期間(年度):2015-04-01 - 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「肝細胞癌における肝幹細胞形質と上皮間葉移行発現に対する画像バイオマーカーの検討」課題番号15K19780\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K19780/15K19780seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院放射線科","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00055855","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30721930"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30721930","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K19780/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K19780/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K19780/15K19780seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K19780/15K19780seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-10-18"}],"displaytype":"detail","filename":"HO-PR-YONEDA-N-kaken 2018-6p.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-YONEDA-N-kaken 2018-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/49543/files/HO-PR-YONEDA-N-kaken 2018-6p.pdf"},"version_id":"72ef57d4-3b71-4637-bb97-723d0d06e5ee"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"肝細胞癌における肝幹細胞形質と上皮間葉移行発現に対する画像バイオマーカーの検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肝細胞癌における肝幹細胞形質と上皮間葉移行発現に対する画像バイオマーカーの検討"},{"subitem_title":"The investigation of imaging biomarkers predicting hepatic stem cell feature and epithelial-mesenchymal transition feature in hepatocellular carcinoma","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-10-18"},"publish_date":"2019-10-18","publish_status":"0","recid":"49543","relation_version_is_last":true,"title":["肝細胞癌における肝幹細胞形質と上皮間葉移行発現に対する画像バイオマーカーの検討"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:49:34.361039+00:00"}