{"created":"2023-07-27T06:54:48.044371+00:00","id":50310,"links":{},"metadata":{"_buckets":{"deposit":"cc1462c5-c24a-4d43-9685-3fa226289abe"},"_deposit":{"created_by":18,"id":"50310","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"50310"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00050310","sets":["2812:2813:3929"]},"author_link":["91114","91115"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05-20","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"11p.","bibliographicVolumeNumber":"2016-04-01 - 2020-03-31","bibliographic_titles":[{"bibliographic_title":"令和1(2019)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2019 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、IgG4関連疾患における線維化・硬化病態について、ヒト組織検体やモデルマウスであるLAT Y136F変異マウスを用いて検討した。ヒト臓器病変の線維化・硬化について、解剖学的部位によりコラーゲンの型が異なること、線維化・硬化進展に伴い線維性コラーゲンであるⅠ・Ⅲ型コラーゲンが増加することを見出した。B細胞活性化・形質細胞分化を促進するAPRILと病理組織との関連を検討し、線維化に関与するM2マクロファージがAPRILを産生し、病理像形成に寄与することを示した。LAT Y136F変異マウスにおいて、週齢とともに各臓器病変線維化スコアの上昇を確認し、病変局所のAPRIL発現が確認された。","subitem_description_type":"Abstract"},{"subitem_description":"In this study, using human specimens from affected organs and LAT Y136F knock-in mouse as model mouse, we investigated pathophysiology of fibrosis and sclerosis in IgG4-related disease (IgG4-RD). We have clarified the differences of types of collagen according to the anatomical locations and increase of fibril-forming collagens (collagen I and III) in parallel with progression of fibrosis and sclerosis. We have also clarified that M2 macrophages, that are implicated in fibrosis in IgG4-RD, produce APRIL promoting activation, proliferation, and survival of B lymphocytes and plasma cells, and contribute to the formation of characteristic pathology. In LAT Y136F knock-in mouse, we have found an increase of fibrosis score as mouse got older and enhanced expression of APRIL in affected organs.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16K19597, 研究期間(年度):2016-04-01 - 2020-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「モデルマウスを用いたIgG4関連疾患における線維化・硬化病態の解明と治療法の確立」研究成果報告書　課題番号16K19597\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K19597/16K19597seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院研修医・専門医総合教育センター","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00056619","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50645124"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50645124","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K19597/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K19597/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K19597/16K19597seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K19597/16K19597seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-16"}],"displaytype":"detail","filename":"HO-PR-MIZUSHIMA-I-kaken 2020-11p.pdf","filesize":[{"value":"616.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-MIZUSHIMA-I-kaken 2020-11p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/50310/files/HO-PR-MIZUSHIMA-I-kaken 2020-11p.pdf"},"version_id":"6aa9d05e-59ec-4817-81b6-dc650decb397"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"モデルマウスを用いたIgG4関連疾患における線維化・硬化病態の解明と治療法の確立","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"モデルマウスを用いたIgG4関連疾患における線維化・硬化病態の解明と治療法の確立"},{"subitem_title":"Elucidation of pathophysiology of fibrosis and sclerosis and establishment of treatment in IgG4-related disease using model mouse","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["3929"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-04-16"},"publish_date":"2021-04-16","publish_status":"0","recid":"50310","relation_version_is_last":true,"title":["モデルマウスを用いたIgG4関連疾患における線維化・硬化病態の解明と治療法の確立"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:02:35.319066+00:00"}