{"created":"2023-07-27T06:54:50.574525+00:00","id":50383,"links":{},"metadata":{"_buckets":{"deposit":"112dc34e-3a05-45ba-8516-a8c90fc392f8"},"_deposit":{"created_by":18,"id":"50383","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"50383"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00050383","sets":["2812:2813:2815"]},"author_link":["3006","27243"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-06-19","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2016-04-01 - 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"核磁気共鳴イメージング (MRI)は天然同位体に利用可能であるため、腫瘍における化合物の蓄積を可視的に評価できる可能性を持つ。本研究ではがんに高発現するペプチドトランスポーター（PEPT）を標的とし、フッ素誘導体PEPT基質の核磁気共鳴イメージング (MRI)プローブとしての有用性を検証することを目的とした。結果として、PEPT1およびPEPT2に良好な基質の合成に成功し、そのうち良好なMRIプローブとして期待された化合物のマウスにおける体内動態特性を調べた。一方、MRI解析を行った結果、すい臓がん細胞の担がんマウスモデルでは腫瘍への良好な集積は確認されなかった。","subitem_description_type":"Abstract"},{"subitem_description":"Magnetic resonance imaging (MRI) is available for natural isotopes, which has the potential to be able to visually assess the accumulation of compounds in tumors. In the present study, we aimed to synthesize a novel MRI probe targeting peptide transporters (PEPT) that are highly expressed in cancer. As a result, we succeeded in synthesis of good substrates for PEPT1 and PEPT2, among which the pharmacokinetic characteristics of the compound expected as a good MRI probe were investigated in mice. On the other hand, favorable tumor accumulation was not observed in xenograft mouse models of pancreatic cancer cells by MRI analysis.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16K18865, 研究期間(年度):2016-04-01 - 2019-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「核磁気共鳴法を利用したペプチドトランスポーター標的型がん診断プローブの創出」課題番号16K18865\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K18865/16K18865seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00056692","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域薬学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=40709028"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=40709028","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K18865/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K18865/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K18865/16K18865seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K18865/16K18865seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-05-18"}],"displaytype":"detail","filename":"PH-PR-ARAKAWA-H-kaken 2019-4p.pdf","filesize":[{"value":"350.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-ARAKAWA-H-kaken 2019-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/50383/files/PH-PR-ARAKAWA-H-kaken 2019-4p.pdf"},"version_id":"4ec7c9be-5662-4846-b8ce-ffc7ff292cfd"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"核磁気共鳴法を利用したペプチドトランスポーター標的型がん診断プローブの創出","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"核磁気共鳴法を利用したペプチドトランスポーター標的型がん診断プローブの創出"},{"subitem_title":"Drug discovery for peptide transporter targeting cancer diagnostic probe using magnetic Resonance Imaging","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-05-18"},"publish_date":"2020-05-18","publish_status":"0","recid":"50383","relation_version_is_last":true,"title":["核磁気共鳴法を利用したペプチドトランスポーター標的型がん診断プローブの創出"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:32:14.467586+00:00"}