{"created":"2023-07-27T06:54:50.619462+00:00","id":50384,"links":{},"metadata":{"_buckets":{"deposit":"a4c079ab-3eeb-444a-820a-842933880148"},"_deposit":{"created_by":18,"id":"50384","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"50384"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00050384","sets":["2812:2813:2816"]},"author_link":["76366","2309"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-28","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2015-04-01 - 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"日本人におけるmiRNA-SNPを網羅的に解析し、健常人における遺伝子頻度に人種差が認められるか、がん患者における分子標的薬の副作用または罹患リスクのバイオマーカーとしてmiR-SNPを利用できるか、明らかにすることを目的とした。約1,900種類のpre-miRNAを対象としたNGS解析の結果、平均して一人あたり150種類のmiRNA-SNPが認められ、既報の遺伝子頻度と比較して人種差が認められるもの存在した。健常人と非細胞肺がん、大腸がん、成人T細胞白血病/リンパ種患者で遺伝子頻度に有意差が認められるmiRNA-SNPも複数認められ、がんの罹患マーカーとして利用できる可能性が示された。","subitem_description_type":"Abstract"},{"subitem_description":"We analyzed the miRNA-SNPs in Japanese subjects targeting 1,900 pre-miRNAs to investigate whether there are ethnic differences in their allele frequencies, and to identify biomarkers, which are useful to predict adverse reactions of anti-cancer drugs or incidence of cancers. Approximately 150 miRNA-SNPs were found in a person on average for healthy subjects and cancer patients. We found several miRNA-SNPs whose frequencies were significantly different with in global populations, suggesting ethnic differences. We identified miRNA-SNPs whose frequencies were different between healthy subjects and non-small cell lung cancer, colorectal cancer, or adult T-cell / leukemia patients. These miRNA-SNPs can be biomarkers of incidence of each cancer.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K14999, 研究期間(年度):2015-04-01 - 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「分子標的薬の副作用回避miRNA-SNPマーカーの探索と個別化療法最適化への挑戦」課題番号15K14999\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K14999/15K14999seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学新学術創成研究機構ナノ生命科学研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00056693","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=70266162"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=70266162","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K14999/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K14999/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K14999/15K14999seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K14999/15K14999seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-27"}],"displaytype":"detail","filename":"PH-PR-NAKAJIMA-M-kaken 2018-4p.pdf","filesize":[{"value":"258.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-NAKAJIMA-M-kaken 2018-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/50384/files/PH-PR-NAKAJIMA-M-kaken 2018-4p.pdf"},"version_id":"f1df3ab0-f254-475c-adc0-644313cf4a8e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"分子標的薬の副作用回避miRNA-SNPマーカーの探索と個別化療法最適化への挑戦","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"分子標的薬の副作用回避miRNA-SNPマーカーの探索と個別化療法最適化への挑戦"},{"subitem_title":"miRNA-SNP analysis as potential biomarkers of adverse reactions by molecular-targeted agents","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-01-27"},"publish_date":"2020-01-27","publish_status":"0","recid":"50384","relation_version_is_last":true,"title":["分子標的薬の副作用回避miRNA-SNPマーカーの探索と個別化療法最適化への挑戦"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:50:48.872820+00:00"}