{"created":"2023-07-27T06:54:50.801227+00:00","id":50391,"links":{},"metadata":{"_buckets":{"deposit":"b05548f6-6c74-4307-97cb-1b9e5d083ba1"},"_deposit":{"created_by":18,"id":"50391","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"50391"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00050391","sets":["2812:2813:2816"]},"author_link":["91214","91215"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-04-27","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2016-08-26 - 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 研究活動スタート支援 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mishiro, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"91215","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60776079","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60776079"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では申請者らが独自に合成法を確立した新規骨格の生理活性物質としての利用可能性開拓、及び物性を活かした新規有機化学反応の開発、分光分析的手法による検出法の開発を行い、それらの成果を統合し、疾患の診断および治療に有用な分子プローブ開発を行うことを目的とし研究を行った。生理活性物質については申請者が独自に開発した骨格を含む目的化合物の合成を達成し、細胞、動物レベルでの動態評価を行い、当該新規骨格を用いる医薬品化学に重要な知見を得た。また、反応開発については光のON/OFFで完全に反応の進行の制御が可能な新規反応開発に成功し、学会、論文発表を行った。","subitem_description_type":"Abstract"},{"subitem_description":"In this research we have accomplished two types of project using highly strained molecules. First project was the development of novel bioactive compounds having highly strained structure. We have succeeded to synthesis the desired product and analysed its activity and biodistribution using nuclear medicine method. We have obtained some important information for the medicinal chemistry using the strained structures. Second project was the development of novel phototriggered reactions using highly strained molecules. We have succeeded to develop a phototriggered dehydration condensation whose progress is completely controllable by ON/OFF states of the light irradiation. The result was published in Org. Lett. 2017, 4912.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16H06824, 研究期間(年度):2016-08-26 - 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「光励起によるin situ活性種生成を利用した新規反応及び生体分子標識法の開発」課題番号16H06824\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16H06824/16H06824seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学新学術創成研究機構","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00056700","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=60776079"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=60776079","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H06824/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H06824/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16H06824/16H06824seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16H06824/16H06824seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"三代, 憲司"}],"nameIdentifiers":[{"nameIdentifier":"91214","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60776079","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60776079"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-27"}],"displaytype":"detail","filename":"FR-PR-MISHIRO-K-kaken 2018-5p.pdf","filesize":[{"value":"665.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"FR-PR-MISHIRO-K-kaken 2018-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/50391/files/FR-PR-MISHIRO-K-kaken 2018-5p.pdf"},"version_id":"c002326b-c0be-4d93-95e6-d5ed9c41234d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"光励起によるin situ活性種生成を利用した新規反応及び生体分子標識法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"光励起によるin situ活性種生成を利用した新規反応及び生体分子標識法の開発"},{"subitem_title":"Development of novel phototriggered reactions and their application to biomolecule labeling","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-01-27"},"publish_date":"2020-01-27","publish_status":"0","recid":"50391","relation_version_is_last":true,"title":["光励起によるin situ活性種生成を利用した新規反応及び生体分子標識法の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:35:00.142588+00:00"}