{"created":"2023-07-27T06:54:51.388419+00:00","id":50405,"links":{},"metadata":{"_buckets":{"deposit":"ee331b92-e366-4dfd-bfd4-6ede145a36a5"},"_deposit":{"created_by":18,"id":"50405","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"50405"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00050405","sets":["2812:2813:2819"]},"author_link":["80321","91231"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-05-23","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2012-04-01 - 2015-03-31","bibliographic_titles":[{"bibliographic_title":"平成26(2014)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2014 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"組織幹細胞の老化は神経変性疾患や癌などの加齢関連疾患の発症に深く関与している。われわれは、クロマチンリモデリング因子CHD8がp53に結合し、アポトーシスを抑制することによって発生期の器官形成に重要な役割を果たしていることを発見した。その後、CHD8はp53誘導性のアポトーシスだけでなく細胞老化も抑制し、強力な発癌活性を示すことが明らかになった。また最近、自閉症スペクトラム障害の最も有力な原因候補遺伝子としてこのCHD8が同定され、世界中で大きな反響を呼んでいる。われわれの研究によって、CHD8は神経幹細胞機能の維持に必須であり、CHD8へテロ欠損マウスは自閉症様症状を呈することが判明した。","subitem_description_type":"Abstract"},{"subitem_description":"Cellular senescence of tissue stem cells are deeply involved in the onset of age-related diseases, such as neurodegenerative diseases and cancer. We found that the chromatin remodeling factor CHD8 binds to tumor suppressor protein p53 and inhibits p53-mediated apoptosis, which plays an important role in organogenesis during embryogenesis. We next revealed that CHD8 inhibits not only p53-induced apoptosis but also cellular senescence and exhibits potent transforming activity. More recently, CHD8 is identified as the most frequently mutated gene in autism spectrum disorder (ASD), which creates a big sensation all over the world. Furthermore, we found that CHD8 is essential for maintenance of neural stem cells and mice heterozygous for CHD8 gene were found to manifest ASD-like phenotypes.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:24501305, 研究期間(年度):2012-04-01 - 2015-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「クロマチンリモデリングによる老化と癌の制御機構の解明」課題番号24501305\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24501305/24501305seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00056714","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系 / 九州大学"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50423562"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50423562","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24501305/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24501305/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24501305/24501305seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24501305/24501305seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-27"}],"displaytype":"detail","filename":"ME-PR-NISHIYAMA-M-kaken 2015-5p.pdf","filesize":[{"value":"135.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-NISHIYAMA-M-kaken 2015-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/50405/files/ME-PR-NISHIYAMA-M-kaken 2015-5p.pdf"},"version_id":"59fa33b0-86d1-4fe7-bf1d-39fb969586e4"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"クロマチンリモデリングによる老化と癌の制御機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"クロマチンリモデリングによる老化と癌の制御機構の解明"},{"subitem_title":"Elucidation of the mechanisms that control aging and cancer by chromatin remodeling","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2819"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-01-27"},"publish_date":"2020-01-27","publish_status":"0","recid":"50405","relation_version_is_last":true,"title":["クロマチンリモデリングによる老化と癌の制御機構の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:51:48.652534+00:00"}