{"created":"2023-07-27T06:54:51.432693+00:00","id":50406,"links":{},"metadata":{"_buckets":{"deposit":"35abb1fc-1c8b-4995-923b-7c42a2916d42"},"_deposit":{"created_by":18,"id":"50406","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"50406"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00050406","sets":["2812:2813:2822"]},"author_link":["80321","91231"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05-18","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2010-2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 若手研究(A) 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"最近われわれは、クロマチンリモデリング因子CHD8がクロマチン上にリンカーヒストンH1を呼び込むことによってp53機能を抑制することを見出したが、CHD8/ヒストンH1複合体は細胞老化におけるクロマチンリモデリングに重要な役割を果たしていることが予想された。そこでまず正常細胞でCHD8を過剰発現し、細胞老化に及ぼす効果について検討したところ、CHD8の強制発現はp53誘導性の細胞老化を抑制することが明らかとなった。次に発現誘導型CHD8トランスジェニックマウスを作製することによって、CHD8が強力なトランスフォーメーション活性を示すことを明らかにした。また正常老化マウスや老化モデルマウスでは、CHD8/ヒストンH1の発現レベルが著明に低下していることが判明しており、さらに正常細胞でヒストンH1をノックダウンすると細胞老化が誘導され、CHD8ノックアウトマウス由来の細胞も同様に細胞老化を来すことが明らかとなった。つまり、CHD8は抗老化作用をもつことが予想されるだけでなく、がん遺伝子として機能する可能性が高いものと考えられた。","subitem_description_type":"Abstract"},{"subitem_description":"We recently have found that a chromatin remodeling factor CHD8 suppresses p53 function by recruiting the linker histone H1 on chromatin, and expected that a CHD8/histone H1 complex may play an important role in chromatin remodeling in cellular senescence. First, we investigated the effect of CHD8 overexpression on cellular senescence in normal cells, and revealed that forced expression of CHD8 inhibits p53-induced cellular senescence. We next generated CHD8-inducible transgenic mice, and revealed that CHD8 has a potent transformating activity. In normal aging or premature aging mice, we found that the expression level of CHD8/histone H1 is markedly decreased. Furthermore, we found that cellular senescence is induced in histone H1-knockdown cells or the cells derived from CHD8-knockout mice. Taken together, it is expected that CHD8 not only has anti-aging effect, but also functions as an oncogene.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:22680061, 研究期間(年度):2010-2011","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「CHD8/ヒストンH1複合体による老化とがんのエピジェネティック制御機構の研究」課題番号22680061\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22680061/22680061seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系 / 九州大学","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00056715","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50423562"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50423562","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22680061/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22680061/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22680061/22680061seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22680061/22680061seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-27"}],"displaytype":"detail","filename":"ME-PR-NISHIYAMA-M-kaken 2012-5p.pdf","filesize":[{"value":"27.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-NISHIYAMA-M-kaken 2012-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/50406/files/ME-PR-NISHIYAMA-M-kaken 2012-5p.pdf"},"version_id":"1806ab52-f732-4835-b812-4a20592245d3"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"CHD8/ヒストンH1複合体による老化とがんのエピジェネティック制御機構の研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"CHD8/ヒストンH1複合体による老化とがんのエピジェネティック制御機構の研究"},{"subitem_title":"Research on epigenetic regulation aging and cancer by CHD8/histone H1 complex","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-01-27"},"publish_date":"2020-01-27","publish_status":"0","recid":"50406","relation_version_is_last":true,"title":["CHD8/ヒストンH1複合体による老化とがんのエピジェネティック制御機構の研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:24:45.150904+00:00"}