{"created":"2023-07-27T06:54:51.566196+00:00","id":50409,"links":{},"metadata":{"_buckets":{"deposit":"9cc094c5-c829-4232-b63f-cfea81c74c40"},"_deposit":{"created_by":18,"id":"50409","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"50409"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00050409","sets":["2812:2813:2818"]},"author_link":["91235","91236"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-05-31","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2014-04-01 - 2016-03-31","bibliographic_titles":[{"bibliographic_title":"平成27(2015)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書"},{"bibliographic_title":"2015 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ino, Daisuke"}],"nameIdentifiers":[{"nameIdentifier":"91236","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40721981","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40721981"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"感覚や運動の高速な情報伝達の要となるのが有髄神経に存在するRanvier 絞輪であり、その機能破綻は様々な病気の原因となりうると想定されている。本研究では、個体内においてRanvier 絞輪を標識し、非破壊的に観察する手法を開発することで、Ranvier 絞輪が異常時にどのように動的な変化するかを明らかにすることを目指した。特に、Ranvier絞輪を標識する蛍光プローブを開発し、本プローブをアデノ随伴ウイルスによりマウス脊髄軸索に発現させ、病態時のRanvier絞輪周辺の動的な変化を解析した。","subitem_description_type":"Abstract"},{"subitem_description":"Nodes of Ranvier play a pivotal role in fast transmission of sensory- and motor information in the peripheral nervous system, and disruption of nodes of Ranvier can be a cause of various neurological diseases. To gain the insight into how disruption of nodes of Ranvier occurs during the disease progression, we aimed to develop a method that allows analysis of nodes of Ranvier dynamics in the intact tissue. We developed a fluorescent probe that labels nodes of Ranvier. By expressing this probe in mice spinal cord using AAV vector, we analyzed the morphological changes nodes of Ranvier in diseased nerves.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26670120, 研究期間(年度):2014-04-01 - 2016-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「動的イメージングによるRanvier絞輪内分子動態の解明」課題番号:26670120\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26670120/26670120seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系 / 理化学研究所 / 東京大学","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00056718","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=40721981"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=40721981","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26670120/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26670120/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26670120/26670120seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26670120/26670120seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"稲生, 大輔"}],"nameIdentifiers":[{"nameIdentifier":"91235","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40721981","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40721981"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-27"}],"displaytype":"detail","filename":"ME-PR-INO-D-kaken 2016-4p.pdf","filesize":[{"value":"145.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-INO-D-kaken 2016-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/50409/files/ME-PR-INO-D-kaken 2016-4p.pdf"},"version_id":"1cb6efb4-1582-406c-8fd0-411990cfdef9"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"動的イメージングによるRanvier絞輪内分子動態の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"動的イメージングによるRanvier絞輪内分子動態の解明"},{"subitem_title":"Imaging-based analysis of nodes of Ranvier dynamics","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-01-27"},"publish_date":"2020-01-27","publish_status":"0","recid":"50409","relation_version_is_last":true,"title":["動的イメージングによるRanvier絞輪内分子動態の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:44:38.619721+00:00"}