{"created":"2023-07-27T06:54:51.655708+00:00","id":50411,"links":{},"metadata":{"_buckets":{"deposit":"5c927f87-784a-41f4-b1e5-a487609711ba"},"_deposit":{"created_by":18,"id":"50411","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"50411"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00050411","sets":["2812:2813:2817"]},"author_link":["91239","91240"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-06-15","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2015-04-01 - 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ishikawa, Tatsuya"}],"nameIdentifiers":[{"nameIdentifier":"91240","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00750209","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=00750209"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究はミラーイメージペイン発症に一次体性感覚野(S1)の神経回路再編が関与するか検討する事を目的とした。慢性疼痛時、患肢と同側のS1では1層抑制性神経細胞およびアストロサイトの活動亢進が認められ、2/3層錐体細胞の活動は抑制されている事を見出した。この抑制活動をGABAA受容体の拮抗薬により慢性的に抑制すると、神経回路再編が生じ健常肢に疼痛様行動が誘発されたが、アストロサイトの活動を抑制すると、これら現象が生じない事を明らかにした。したがって、ミラーイメージペイン発症にはS1の神経回路再編が関与しており、再編には興奮性神経細胞およびアストロサイトの活動亢進が必要であると示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Some chronic pain patients have an abnormal pain sensation in contralateral limb to injury, which is called mirror image pain. Since synaptic remodeling in the primary somatosensory cortex (S1) has critical roles in induction of chronic pain, cortical reorganization in the S1 ipsilateral to injured limb may contribute to mirror image pain. However, contribution of cortical cells in the S1 in mirror image pain remain completely unknown.\nIn the present study, we found that inhibitory neuronal activities and astrocytic activities increased in the S1, while excitatory neuronal function decreased. Disinhibition of ipsilateral S1 induced by chronic application of GABAA receptor antagonist caused enhancement of neuronal activities, synaptic remodeling and chronic pain, and these are blocked by inhibition of astrocytic activities. Therefore, present results indicate that disinhibition of ipsilateral S1 to injured limb may contribute to induction of mirror image pain with synaptic remodeling.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K21604, 研究期間(年度):2015-04-01 - 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「慢性疼痛発症における一次体性感覚野の役割: ニューロン・グリア連関の解明」研究成果報告書　課題番号15K21604\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K21604/15K21604seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系 / 福井大学","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00056720","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=00750209"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=00750209","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K21604/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K21604/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K21604/15K21604seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K21604/15K21604seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"石川, 達也"}],"nameIdentifiers":[{"nameIdentifier":"91239","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00750209","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=00750209"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-27"}],"displaytype":"detail","filename":"ME-PR-ISHIKAWA-T-kaken 2017-4p.pdf","filesize":[{"value":"163.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-ISHIKAWA-T-kaken 2017-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/50411/files/ME-PR-ISHIKAWA-T-kaken 2017-4p.pdf"},"version_id":"38fc902a-7ed9-4699-a97e-f90989b6a9c9"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"慢性疼痛発症における一次体性感覚野の役割: ニューロン・グリア連関の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"慢性疼痛発症における一次体性感覚野の役割: ニューロン・グリア連関の解明"},{"subitem_title":"The role of primary somatosensory cortex in chronic pain","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-01-27"},"publish_date":"2020-01-27","publish_status":"0","recid":"50411","relation_version_is_last":true,"title":["慢性疼痛発症における一次体性感覚野の役割: ニューロン・グリア連関の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:39:16.471557+00:00"}