{"created":"2023-07-27T06:54:51.700343+00:00","id":50413,"links":{},"metadata":{"_buckets":{"deposit":"0972b7f4-c563-4f00-9320-99f0f29a598f"},"_deposit":{"created_by":18,"id":"50413","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"50413"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00050413","sets":["2812:2813:2817"]},"author_link":["91243","91242"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05-25","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2014-04-01 - 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究ではIgG4関連疾患（IgG4-RD）におけるAPRILの意義について検討した。IgG4関連腎臓病患者の腎組織において、APRILの発現亢進及び治療後の発現低下が認められた。主なAPRIL産生細胞はM2マクロファージであった。IgG4-RDのモデル動物であるLat Y136F knock-in miceにおいても病変部位にAPRILの発現を認め、APRIL阻止抗体の投与により腎病変の進展が抑制された。さらに、ヒトおよびLat Y136F knock-in miceの病変部位にBAFFの高発現も認めた。以上より、IgG4-RDの病態形成にAPRILおよびBAFFが関与していると考えられた。","subitem_description_type":"Abstract"},{"subitem_description":"The purpose of this study was to analyze the role of a proliferation-inducing ligand (APRIL) in patients with IgG4-related disease (IgG4-RD). APRIL was expressed in kidney inflammation, and corticosteroid treatment decreased the expression of APRIL in the renal tissue of patients with IgG4-related kidney disease. We found that the main APRIL-producing cells were M2 macrophages. We also confirmed the expression of APRIL in the inflammatory lesion of Lat Y136F knock-in mice. Treatment with APRIL-blocking antibody suppressed the development of the kidney lesions in these mice. Furthermore, we confirmed the high expression level of BAFF in the lesions of patients with IgG4-RD and Lat Y136F knock-in mice. These data indicate that APRIL and BAFF are related to the pathogenesis of IgG4-RD.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26461487, 研究期間(年度):2014-04-01 - 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「モデルマウスを用いたIgG4関連疾患の病態の解明と治療法の確立」研究成果報告書　課題番号26461487\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26461487/26461487seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院リウマチ・膠原病内科","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00056722","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20361983"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20361983","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26461487/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26461487/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26461487/26461487seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26461487/26461487seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-27"}],"displaytype":"detail","filename":"HO-PR-KAWANO-M-kaken 2017-6p.pdf","filesize":[{"value":"189.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-KAWANO-M-kaken 2017-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/50413/files/HO-PR-KAWANO-M-kaken 2017-6p.pdf"},"version_id":"9f9c9894-4171-4202-acb4-1e8000fce8ec"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"モデルマウスを用いたIgG4関連疾患の病態の解明と治療法の確立","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"モデルマウスを用いたIgG4関連疾患の病態の解明と治療法の確立"},{"subitem_title":"Elucidation of a pathogenesis of IgG4-related disease and establishment of a novel treatment","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-01-27"},"publish_date":"2020-01-27","publish_status":"0","recid":"50413","relation_version_is_last":true,"title":["モデルマウスを用いたIgG4関連疾患の病態の解明と治療法の確立"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:14:16.449232+00:00"}