{"created":"2023-07-27T06:54:52.059537+00:00","id":50421,"links":{},"metadata":{"_buckets":{"deposit":"7be6fc3d-e17f-4bdd-9861-a000bd8a61f7"},"_deposit":{"created_by":18,"id":"50421","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"50421"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00050421","sets":["2812:2813:2816"]},"author_link":["2442","91255"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-06-26","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2015-04-01 - 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"RFPを遺伝子導入したヒト前立腺癌細胞PC-3（PC-3-RFP）を用いた．In vitro実験として，PC-3-RFP細胞をGSK-3β阻害薬（SB216763，AR-A014418）で10日間刺激し，細胞のコロニー形成を評価したところ，GSK-3β阻害薬は濃度依存的に腫瘍を抑制していた．また，in vivo実験としてヌードマウスの脛骨にPC-3-RFP細胞を注射することにより前立腺癌の骨転移モデルを作成し，GSK-3β阻害薬を腹腔内投与しところ，腫瘍の蛍光面積，腫瘍の体積，腫瘍の重量は有意に抑制されていた．","subitem_description_type":"Abstract"},{"subitem_description":"The human prostate cancer PC-3 cells were genetically engineered to express RFP using a retrovirus. The cells were treated with SB216763 or AR-A014418 and evaluated by clonogenic assay. In the in vitro study, GSK-3β inhibitor inhibited proliferation of PC-3-RFP cells in a dose-dependent manner. PC-3-RFP cells in Matrigel were injected into the intramedullary cavity of the left tibia. One week after intratibial injection of cancer cells, the mice were treated by SB216763 or AR-A014418. GSK-3β inhibitors significantly reduced the fluorescent area of the tumor, tumor volume, and tumor weight.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16K20042, 研究期間(年度):2015-04-01 - 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「癌骨転移に対する新規治療法の開発」課題番号16K20042\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K20042/16K20042seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系 / 名古屋市立大学","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00056730","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=40753455"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=40753455","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K20042/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K20042/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K20042/16K20042seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K20042/16K20042seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-27"}],"displaytype":"detail","filename":"ME-PR-MIWA-S-kaken 2018-6p.pdf","filesize":[{"value":"207.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-MIWA-S-kaken 2018-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/50421/files/ME-PR-MIWA-S-kaken 2018-6p.pdf"},"version_id":"8bf8beaa-05e3-4fc9-bbb8-d2039936af5e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"癌骨転移に対する新規治療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"癌骨転移に対する新規治療法の開発"},{"subitem_title":"Novel treatment for metastatic bone tumors","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-01-27"},"publish_date":"2020-01-27","publish_status":"0","recid":"50421","relation_version_is_last":true,"title":["癌骨転移に対する新規治療法の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:50:59.033998+00:00"}