{"created":"2023-07-27T06:54:53.372930+00:00","id":50454,"links":{},"metadata":{"_buckets":{"deposit":"f8e729dc-af7d-480d-a2c7-5b7469339433"},"_deposit":{"created_by":18,"id":"50454","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"50454"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00050454","sets":["2812:2813:2820"]},"author_link":["91308","139"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-06-02","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2011-04-01 - 2014-03-31","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 若手研究(A) 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"内用療法に利用可能なα放射体の中で、半減期7.2時間の211Atは最も臨床応用が期待されている。しかし半減期が短いためその利用は大型サイクロトロン施設近辺に制限されている。本研究では、211Atの広範囲における国内実用化を目指し、有機溶媒抽出系を用いた211Rn/211Atジェネレータの製造を行った。核反応で製造した211Rnをターゲットから分離して有機溶媒中に捕集し、次に211Rnから成長する211Atを水溶液およびメタノール中に回収した。標的内に製造された211Rnは82%を有機相へ抽出することができ、また、211Rnから生成した211Atのメタノール溶媒への回収率は98%であった。","subitem_description_type":"Abstract"},{"subitem_description":"Although an alpha emitter astatine-211 is the most promising raddionuclide for treatment of cancer, its short half-life limited the use of it only at nearby hospitals. Here we produced 211Rn/211At generator using solvent extraction method, which enables to deliver 211At more distant site from product facilities.\n211Rn was prodcued by 209Bi(7Li, 5n)211Rn reaction at the JAEA-Tokai tandem accelerator. The irradiated target was dissolved in dilute nitric acid and 211Rn was extracted by solvent extraction using dodecane as a organic solvent. The dodecane was stand for 12 hours to generate 211At, then 211At was back extracted using methanol. It was found that exraction rate of 211Rn into dodecane was 82% while target material and other by-product radionuclides were hardly extracted. The recovery yield of 211At form dodecane to methanol was 98%.\nThese results showed that 211Rn/211At generator using solvent extraction system is easy to handle and will be feasible product.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23689056, 研究期間(年度):2011-04-01 - 2014-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「遠隔地RI治療を目指した短半減期アルファ放射体211Atジェネレータの製造と応用」研究成果報告書　課題番号23689056\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23689056/23689056seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00056763","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域保健学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80313675"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80313675","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23689056/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23689056/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23689056/23689056seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23689056/23689056seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-03"}],"displaytype":"detail","filename":"ME-PR-WASHIYAMA-K-kaken 2014-5p.pdf","filesize":[{"value":"139.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-WASHIYAMA-K-kaken 2014-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/50454/files/ME-PR-WASHIYAMA-K-kaken 2014-5p.pdf"},"version_id":"3ec6cad3-f69c-4b48-ba63-cf9dd08074fc"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"遠隔地RI治療を目指した短半減期アルファ放射体211Atジェネレータの製造と応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"遠隔地RI治療を目指した短半減期アルファ放射体211Atジェネレータの製造と応用"},{"subitem_title":"Production and application of generator system of short-lived alpha emitter 211At for radionuclide therapy in a remote location","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-02-03"},"publish_date":"2020-02-03","publish_status":"0","recid":"50454","relation_version_is_last":true,"title":["遠隔地RI治療を目指した短半減期アルファ放射体211Atジェネレータの製造と応用"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:11:17.737149+00:00"}