{"created":"2023-07-27T06:54:53.462765+00:00","id":50456,"links":{},"metadata":{"_buckets":{"deposit":"fd0bfadf-0fbf-4c79-ab2b-985a47fe46d8"},"_deposit":{"created_by":18,"id":"50456","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"50456"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00050456","sets":["2812:2813:2823"]},"author_link":["91308","139"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-05-19","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2008-2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、加速器を用いた核反応で製造した^<230>Paを利用して、^<230>U/^<226>Thジェネレータの製造法を検討した。また、ミルキングした^<226>Thで標識した^<226>Th-EDTMPの骨集積に関する検討を行った。その結果、比較的簡単な化学分離で^<230>U/^<226>Thジェネレータを製造することに成功し、さらにミルキングした^<226>Thの標識化合物^<226>Th-EDTMPをマウスに尾静脈投与し、^<226>Th-EDTMPの骨への集積を確認した。","subitem_description_type":"Abstract"},{"subitem_description":"Targeted alpha therapy (TAT) has been applied for cancer therapy and many clinical studies have been performed. Uranium-230 is a promising cyclotron produced alpha-emitting radionuclide for TAT. According to the reaction ^<232>Th(p, 3n)^<230>Pa and following the β- decay of ^<230>Pa, ^<230>U can be produced within the irradiated target. The daughter of ^<230>U, ^<226>Th (T_<1/2>=31m) provides a rapid cascade of 4 alpha particles with a 27.7MeV of total energy. In this study, we investigated the availability of production and radiochemical separation of ^<230>U and its daughters. Protactinium-230 was produced by irradiation of ^<232>ThO_2 target. After irradiation, the target was separated and ^<230>U/^<226>Th generator was constructed. Eluted ^<226>Th from generator was radiolabeled with bone seeking chelate, EDTMP and injected into mice for biodistribution evaluation. Most of all radioactivity were retained on bone.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"出典：研究課題「加速器生産α線放出核種の内用放射療法への適応」課題番号20790886\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20790886/20790886seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域保健学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00056765","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80313675"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80313675","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790886/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790886/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20790886/20790886seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20790886/20790886seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-03"}],"displaytype":"detail","filename":"ME-PR-WASHIYAMA-K-kaken 2011-4p.pdf","filesize":[{"value":"235.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-WASHIYAMA-K-kaken 2011-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/50456/files/ME-PR-WASHIYAMA-K-kaken 2011-4p.pdf"},"version_id":"a6d15c42-4d53-4893-a1ca-1f2e21de4fac"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"加速器生産α線放出核種の内用放射療法への適応","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"加速器生産α線放出核種の内用放射療法への適応"},{"subitem_title":"An application of accelerator produced alpha-emitting radionuclide for radionuclide therapy","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-02-03"},"publish_date":"2020-02-03","publish_status":"0","recid":"50456","relation_version_is_last":true,"title":["加速器生産α線放出核種の内用放射療法への適応"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:21:44.344385+00:00"}