{"created":"2023-07-27T06:54:56.204019+00:00","id":50522,"links":{},"metadata":{"_buckets":{"deposit":"6802c7f9-dbfa-4e06-b42c-d07a00f72892"},"_deposit":{"created_by":18,"id":"50522","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"50522"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00050522","sets":["2812:2813:2821"]},"author_link":["91474","336"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-05-15","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2010-2012","bibliographic_titles":[{"bibliographic_title":"平成24(2012)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2012 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"CD38は細胞内カルシウムイオン(Ca2+)上昇に働くセカンドメッセンジャーであるサイクリックADPリボース合成酵素としての働きを有する。質量分析によりCD38に結合するキナーゼ (PKと略) を見いだしたので、CD38により活性化する生理作用がPKの調節を受けるかを検討した。CD38発現細胞ではCa2+振動などCa2+シグナル増強作用がみられ、PK阻害によりこの効果は抑制された。よってCD38により増強する細胞内Ca2+シグナルにPKが関与していることがわかった。","subitem_description_type":"Abstract"},{"subitem_description":"Human CD38 has enzymatic function that catalyzes multiple reactions to produce Ca2+-mobilizing second messenger, cyclic ADP-ribose. In this study, we try to detect CD38-interacting proteins those may influence CD38 activity using proteomic analysis. We find protein kinase (PK) as a binding partner of CD38, and show that enhanced Ca2+signaling including cytosolic Ca2+oscillations were suppressed by inhibition of PK. Therefore it is suggested that PK is involved in activation mechanism of CD38.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:22590202, 研究期間(年度):2010-2012","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「サイクリックADPリボース合成酵素CD38を活性化する細胞内シグナルの解明」課題番号22590202\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22590202/22590202seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00056831","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=10272957"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=10272957","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590202/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590202/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22590202/22590202seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22590202/22590202seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-07"}],"displaytype":"detail","filename":"CH-PR-HASHII-M-kaken 2013-4p.pdf","filesize":[{"value":"397.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CH-PR-HASHII-M-kaken 2013-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/50522/files/CH-PR-HASHII-M-kaken 2013-4p.pdf"},"version_id":"b1c6525e-6b9b-4547-a81f-c517514e72c2"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"サイクリックADPリボース合成酵素CD38を活性化する細胞内シグナルの解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"サイクリックADPリボース合成酵素CD38を活性化する細胞内シグナルの解明"},{"subitem_title":"Activation mechanism of cyclic ADP-ribose-synthesizing enzyme CD38","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2821"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-02-07"},"publish_date":"2020-02-07","publish_status":"0","recid":"50522","relation_version_is_last":true,"title":["サイクリックADPリボース合成酵素CD38を活性化する細胞内シグナルの解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:01:37.630977+00:00"}