{"created":"2023-07-27T06:54:56.429084+00:00","id":50528,"links":{},"metadata":{"_buckets":{"deposit":"38025e07-b8ac-46a5-8614-18c486a92ed0"},"_deposit":{"created_by":18,"id":"50528","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"50528"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00050528","sets":["2812:2813:2835"]},"author_link":["22213","20313"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999-03","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"18p.","bibliographicVolumeNumber":"1997-1998","bibliographic_titles":[{"bibliographic_title":"平成10(2020)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"1998 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"実験腎炎モデルであるWistar Kyotoラット抗GBM抗体腎炎による抗MCAF/MCP-1抗体療法の検討では,抗MCAF/MCP-1抗体を抗GBM抗体と同時投与することにより単球/マクロファージ浸潤の約25%減少と半月体形成率の抑制にくわえ,発症6日目までの蛋白尿抑制を確認した.さらに発症56日目の腎機能低下ならびに糸球体硬化がこの抗体初期投与により抑制された.一方,腎炎惹起7日目に抗MCAF/MCP-1抗体を初回あるいは追加投与した場合,発症後7日目のみの抗体投与群では腎炎惹起14日目における単球/マクロファージ浸潤数は対照群と比較して有意に増加した.これより腎局所で産生されたMCAF/MCP-1が,腎炎発症早期の単球・マクロファージ浸潤・活性化を介して半月体形成性腎炎の発症・進展過程に重要な役割をはたしていることが推測された.\nさらに,ヒト腎炎におけるケモカインと接着因子の動態に関して各種腎炎におけるIL-8,MCAF/MCP-1,EotaxinとCD62p(P-selectin),ICAM-1を免疫組織化学ならびに高感度免疫酵素抗体法により検討した.尿中MCAF/MCP-1はループス腎炎(WHOIV型)ならびに高度の尿蛋白を伴う進行したIgA腎症においで上昇し,尿細管上皮を中心にmRNAならびに蛋白発現が確認された.さらに糸球体におけるCD62p,ICAM-1とIL-8発現は白血球浸潤を伴う急性期糸球体障害において亢進し,これと平行した可溶性分子の血清レベルでの増加が認められた.さらに間質内の好酸球浸潤例において尿中Eotaxinの増加を認めた.これよりヒトにおいてもケモカインあるいは可溶性接着因子の測定は臨床上有用と考えられた.","subitem_description_type":"Abstract"},{"subitem_description":"We investigated the pathophysiological roles of a potent macrophage (Mphi) chemokine, monocyte chemotactic and activating factor (MCAF/MCP-1), in a crescentic glomerulonephritis model of Wistar-Kyoto rats. Anti-MCAF/MCP-1 antibodies decreased proteinuria on day 3 and 6, and also decreased the number of Mphi in glomeruli and crescentic formation in nephritic rats. Furthermore, anti-M CAF/MCP- 1 antibodies remarkably reduced glomerulosclerosis and improved renal dysfunction on day 56. The single administration of anti-MCAF/MCP- I antibodies on day 7 decreased necrotizing lesions and increase of proteinuria as compared with control lgG treated rats. These results suggest that MCAF/MCP-1 essentially participates in the impairment of renal functions associated with crescentic glomerulonephritis by both recruitin2 and activating Mphi in the early phase. We also investigated the involvement of chemokines and the expression of adhesion molecules in human nephritis. Urinary and serum MCAF/MCP-1 levels were significantly high in patients with lupus nephritis including WHO lVb/c. in addition, MCAF and IL-S were differentially expressed in kidneys with IgA nephropathy, and their subtypes. P-selectin and IL-8 were expressed in glomeruli of proliferative glomerulonephritis and were correlated with endocapillary proliferation, CD4Ib (activated platelets) and leukocyte infiltration.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:09671157, 研究期間(年度):1997-1998","subitem_description_type":"Other"},{"subitem_description":"出典：「ヒト腎炎におけるケモカインの意義ならびに抗ケモカイン療法の基礎的検討」研究成果報告書　課題番号09671157\n  (KAKEN：科学研究費助成事業データベース（国立情報学研究所）)\n　　　本文データは著者版報告書より作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00056837","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学附属病院"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50191531"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50191531","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671157/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671157/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-09671157/096711571998kenkyu_seika_hokoku_gaiyo/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-09671157/096711571998kenkyu_seika_hokoku_gaiyo/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-07"}],"displaytype":"detail","filename":"HO-PR-YOKOYAMA-H-kaken 1999-18p.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-YOKOYAMA-H-kaken 1999-18p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/50528/files/HO-PR-YOKOYAMA-H-kaken 1999-18p.pdf"},"version_id":"2dfd13e6-0797-4515-a327-e577c46b8ade"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ヒト腎炎におけるケモカインの意義ならびに抗ケモカイン療法の基礎的検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト腎炎におけるケモカインの意義ならびに抗ケモカイン療法の基礎的検討"},{"subitem_title":"The role of chemokine in human nephritis and basic research of anti-chemokine therapy in experimental nephritis model","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2835"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-02-07"},"publish_date":"2020-02-07","publish_status":"0","recid":"50528","relation_version_is_last":true,"title":["ヒト腎炎におけるケモカインの意義ならびに抗ケモカイン療法の基礎的検討"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:49:21.096281+00:00"}