{"created":"2023-07-27T06:54:57.274213+00:00","id":50547,"links":{},"metadata":{"_buckets":{"deposit":"ce19d136-e649-42c0-a305-ed0c472baa98"},"_deposit":{"created_by":18,"id":"50547","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"50547"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00050547","sets":["2812:2813:2817"]},"author_link":["91507","2755"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05-16","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2014-04-01 - 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"主要な内因性カンナビノイドである2-AGおよびその代謝産物が脳機能にどのような影響を及ぼすのかを調べるため、ラット培養海馬ニューロンを用いた電気生理学的実験およびマウスの3レバー・オペラント課題の行動解析を行い、以下の結論を得た。（1）2-AGおよびその代謝産物は、カンナビノイドCB1受容体を介さずにシナプス活動を上昇させる。（2）CB1受容体の基礎的活性はシナプス活動の維持に寄与している。（3）2-AG／CB1受容体シグナルは、行動の柔軟性に関与している。","subitem_description_type":"Abstract"},{"subitem_description":"Roles of the major endocannabinoid 2-AG and its metabolites in brain functions were examined by measuring electrical activities of rat cultured hippocampal neuros and analyzing the performance of mice on three-lever operant task. We found that 2-AG and its metabolites increase the synaptic activity in a CB1-independent manner, that the ligand-independent basal activity of CB1 receptors supports synaptic activity, and that the endocannabinoid system involving 2-AG and CB1 receptors plays a role in behavioral flexibility.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26430013, 研究期間(年度):2014-04-01 - 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「カンナビノイドと他の脂質メディエーターとのクロストーク」研究成果報告書　課題番号26430013\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26430013/26430013seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域保健学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00056856","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=60179025"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=60179025","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26430013/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26430013/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26430013/26430013seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26430013/26430013seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-07"}],"displaytype":"detail","filename":"ME-PR-SHOSAKU-T-kaken 2017-5p.pdf","filesize":[{"value":"318.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-SHOSAKU-T-kaken 2017-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/50547/files/ME-PR-SHOSAKU-T-kaken 2017-5p.pdf"},"version_id":"d67f5b7d-3d29-4f3f-9840-bbbaedc64f89"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"カンナビノイドと他の脂質メディエーターとのクロストーク","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"カンナビノイドと他の脂質メディエーターとのクロストーク"},{"subitem_title":"Cross-talk between endocannabinoids and other lipid mediators","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-02-07"},"publish_date":"2020-02-07","publish_status":"0","recid":"50547","relation_version_is_last":true,"title":["カンナビノイドと他の脂質メディエーターとのクロストーク"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:14:36.605783+00:00"}