{"created":"2023-07-27T06:54:58.148520+00:00","id":50571,"links":{},"metadata":{"_buckets":{"deposit":"34057470-46bc-42ac-95a7-4987834537f9"},"_deposit":{"created_by":18,"id":"50571","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"50571"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00050571","sets":["2812:2813:2841"]},"author_link":["91488","20737"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1994-03-23","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"2p.","bibliographicVolumeNumber":"1991-1992","bibliographic_titles":[{"bibliographic_title":"平成4(1992)年度 科学研究費補助金 一般研究(C) 報告書概要"},{"bibliographic_title":"1992 Fiscal Year Final Research Report Summary","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ECT(エミッション・コンピュータ断層)受容体イメージング解析法の確立のため,抗精神病薬投与動物を用いたインビトロ及びインビボ実験並びにRI標識化合物合成の基礎的研究を試み以下の結果を得た。\n1.抗精神病薬投与ラット(ハロペリドール,クロザピン投与)におけるインビトロ法(インビトロ受容体オートラジオグラフィ法)では,D1,D2,5-HT2のいずれの受容体でも抗精神病薬による受容体占有率の変化は認められなかった。\n2.一方,インビボ法(組織摘出法)では,著明な受容体占有率の変化が認められたのみならず,定型抗精神病薬(ハロペリドール)と非定型抗精神病薬(クロザピン,リスペリドン,RMI)により相違が認められた。すなわちD2受容体占有率は,定型抗精神病薬の方が高値を示したのに対し,D1,5HT2受容体占有率は非定型抗精神病薬の方が高値を示した。これらの結果は臨床的な治療効果(有効性及び副作用)とよく一致しており,インビボ法はより優れた抗精神病薬を開発する方法として優れていると考えられた。なお,速度論的解析は,受容体占有率による評価より多くの情報を提供すると共にECTイメージング解析に応用可能と考えられ,速度論的解析について現在検討中である。\n3.SPECT用Tc-99m標識薬剤の合成に必要な二官能性キレート剤としてのジアミノジチオール(DADT類)は,従来の方法では最終段階で苛酷な反応条件で還元するためDADT類自体を化学反応させてしまう場合があった。そこで合成法の改良を加え,化学的に不安定な官能基(エステル等)を有するDADT類の合成を行ない動物実験等で良好な結果を得た。\n以上よりインビボ系の動物実験はECT受容体定量的解析の基礎的研究に有用と考えられた。","subitem_description_type":"Abstract"},{"subitem_description":"The effects of acute intravenous or chronic subcutaneous haloperidol (HPD) administration on the local cerebral blood flow (LCBF) in 41 regions of the rat brain were studied by means of the quantative autoradiographic N-isopropyl-p- [125-I] iodoamphetamine technique. After acute HPD administrations, the LCBFs decreased in the anterior cingulate cortex, primary motor cortex and primary auditory cortex, and increased the n. habenula. ChronicHPD administration reduced LCBF in the substantia nigra, and increased LCBFs in the n.caudatus-putamen, n.accumbens and n.habenula. No change in LCBF was observed in any cortical region after chronic HPD administratin.\nAn in vivo receptor binding techniques was applied to evaluate the affinities of and clozapine, risperidone, RMI-81582 and haloperidol for dopamine D1, D2, 5- HT2 receptors in the rat brain with [3-H] -SCH23390, [3-H] -YM-09151-2 and [3-H] -Ketanserine as selective ligands. Time course study of receptor occupancy at 25 to 250 min after i ntraperitoneal administrations with the drugs showed higher 5-HT2 occupancies in the frontal cortex and lower D2 occupancies in the striatum of clozapine, riperidone and RMI-81582 than those of haloperidol. The 5-HT2/D2 ratios of occupancy for clozapine, riperidone and RMI-81582 were 6-7 times higher than that for haloperidol. Stable occupancies of D1 were observed only with RMI-81582 and clozapine, the former maintaining the higher occupancy. These results are in agreement with the previous findings obtained under in vitro conditions and may account for some part of the properties of atypical antipsychotic drugs.\nA new ligand, an N-p-lodophenethl diaminodithiol (DADT-IPE), an analog of N- isopropl-p-iodoamphetamine (IMP), was synthesized and subsequently complexed with Tc-99m, using stannous chloride as a reducing agent. Two complexes (a and b) were separated from Tc-99m-DADT-IPE by high performance liquid chromatography. Biodistribution studies suggested that Tc-99m-DADT-IPE (a) has characteristics which are suitable for cerebral perfusion imaging.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:03670542, 研究期間(年度):1991-1992","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「ECT受容体イメージング解析法のための精神神経症患モデル動物を用いた基礎実験」課題番号03670542\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-03670542/036705421992kenkyu_seika_hokoku_gaiyo/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学学際科学実験センター","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00056880","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=90019604"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=90019604","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03670542/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03670542/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-03670542/036705421992kenkyu_seika_hokoku_gaiyo/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-03670542/036705421992kenkyu_seika_hokoku_gaiyo/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-04-14"}],"displaytype":"detail","filename":"ME-PR-MORI-H-kaken 1994-2p.pdf","filesize":[{"value":"90.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-MORI-H-kaken 1994-2p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/50571/files/ME-PR-MORI-H-kaken 1994-2p.pdf"},"version_id":"dfec3e1d-101a-4b23-a43e-a6fa2c1c48ad"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ECT受容体イメージング解析法のための精神神経症患モデル動物を用いた基礎実験","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ECT受容体イメージング解析法のための精神神経症患モデル動物を用いた基礎実験"},{"subitem_title":"A Fundamental study on analysis of ECT imaging using model animals of psycho-neuro disorders","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2841"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-04-14"},"publish_date":"2022-04-14","publish_status":"0","recid":"50571","relation_version_is_last":true,"title":["ECT受容体イメージング解析法のための精神神経症患モデル動物を用いた基礎実験"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:16:51.933864+00:00"}