{"created":"2023-07-27T06:54:58.420798+00:00","id":50578,"links":{},"metadata":{"_buckets":{"deposit":"a8c402a8-be9e-4f2d-a40b-88a9a50b06e1"},"_deposit":{"created_by":18,"id":"50578","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"50578"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00050578","sets":["2812:2813:2833"]},"author_link":["91559","442"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-03-25","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"3p.","bibliographicVolumeNumber":"1998-2000","bibliographic_titles":[{"bibliographic_title":"平成12(2000)年度 科学研究費補助金 基盤研究(C) 研究成果報告書概要"},{"bibliographic_title":"2000 Fiscal Year Final Research Report Summary","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"初年度にウサギ変形性顎関節症モデルを確立し,顎関節円板の転位が関節円板の破壊と変形性顎関節症進行の要因であることを確認した。第2年度には,このモデルに対して臨床的に行われる関節円板整位術を施行した。その結果,関節円板整位術を早期に行った場合,顎関節構成組織の修復と再生,正常関節機能の保持が観察された。しかし,整位術を一次手術後3週目以降に行ったものでも,変形性顎関節症の進行と関節円板の破壊は二次手術を行わなかった場合と同じであり,関節円板整位術の適応限界が示された。現在,この破壊と修復過程に関する酵素活性の影響について免疫組織化学染色標本による検討を行っている。\nまた第3年度からは,変形性顎関節症の原因の一つである下顎頭関節突起の外傷に関する実験的検討を行ってきた。週齢の異なるウサギ顎関節突起に転位脱臼骨折を起こし,骨折の程度と年齢が修復に与える影響に対して検討を行った。その結果,幼若期のウサギにおける関節突起骨折は変位の程度に関わらず,顎関節形態はほぼ完全に修復されることが示された。一方,成熟期のウサギでは変位の小さい骨折の場合は,ほぼ完全な修復がみられたが,転位脱臼骨折の場合,修復は不完全で顎関節形態の完全な回復は認めなかった。このことより,臨床で高頻度に遭遇する変位を伴う成人の下顎頭関節突起骨折では,積極的な観血的整復固定術の適用が示唆された。この修復過程における酵素活性の影響に関しても免疫組織化学染色標本を用いて継続して研究を行っていく予定である。","subitem_description_type":"Abstract"},{"subitem_description":"Anterior disk displacement was induced in the craniomandibular joint of the rabbits. A sutured thread was placed at the antero-lateral margin of retrodiscal tissue and fixed to infra-orbital portion of zygoma after 7mm anterior displacement of the disk. Postoperative changes were assessed at the 2nd, 3rd, 5th, 8th, and 24th week. Disk displacement induced hypertrophy of articular cartilage of the condyle at the 2nd and 3rd week, then developed disk perforation at the 5th week. Subsequently, degenerative arthritic changes were noted. Then, we devised the period of the secondary disk repositioning surgery at the 2nd and 3rd week after experimental disk displacement procedure. Consequently, animals that underwent secondary disk repositioning at the 2nd week showed recovery from hypertrophy and arthritic changes in the cartilage layer. However, secondary operation at the 3rd week showed no recovery, but progressive arthritic changes were noted in the cartilage. Their changes resembled animal condyles without secondary operation. These results indicated a limitation period of the application of disk repositioning procedure for the condition of anterior disk displacement.\nThis project includes another animal experiment relating to mandibular condyle fracture. An artificial rotational dislocation was performed on condyle of adolescent and adult rabbits, then healing process of the fractured fragments were observed. Fractures in the adolescent animals showed complete healing, regardless dislocation angle of the condyle. On the other hand, delayed and incomplete healing of the fractured fragments were noted among adult animals with rotational dislocation of the condyle. These results suggested that open reduction was advocated for condylar fracture in human adults patients. This phenomenon has been continuously investigated with the assessments for enzymatic activities at the fracture site.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:10671869, 研究期間(年度):1998-2000","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「実験的顎関節症モデルに対する組織学的、生化学的研究」課題番号10671869\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-10671869/106718692000kenkyu_seika_hokoku_gaiyo/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00056887","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=00251926"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=00251926","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10671869/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10671869/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-10671869/106718692000kenkyu_seika_hokoku_gaiyo/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-10671869/106718692000kenkyu_seika_hokoku_gaiyo/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-04-14"}],"displaytype":"detail","filename":"HO-PR-TAKATSUKA-S-kaken 2002-3p.pdf","filesize":[{"value":"120.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-TAKATSUKA-S-kaken 2002-3p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/50578/files/HO-PR-TAKATSUKA-S-kaken 2002-3p.pdf"},"version_id":"22ed6e35-99be-4442-9101-c3854d1d8801"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"実験的顎関節症モデルに対する組織学的、生化学的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"実験的顎関節症モデルに対する組織学的、生化学的研究"},{"subitem_title":"Histologic and biochemical assessments on experimentally induced disk displacement of the craniomandibular joints","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2833"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-04-14"},"publish_date":"2022-04-14","publish_status":"0","recid":"50578","relation_version_is_last":true,"title":["実験的顎関節症モデルに対する組織学的、生化学的研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:16:33.051437+00:00"}