{"created":"2023-07-27T06:54:59.957130+00:00","id":50614,"links":{},"metadata":{"_buckets":{"deposit":"3bf5816e-08dd-4549-b8d1-146d5f8c4277"},"_deposit":{"created_by":18,"id":"50614","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"50614"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00050614","sets":["2812:2813:2825"]},"author_link":["20449","91632"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-05-08","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2007-2008","bibliographic_titles":[{"bibliographic_title":"平成20(2008)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2008 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"強皮症モデルマウスであるタイトスキンマウスに抗CD40L抗体を投与した。その結果、タイトスキンマウスの皮膚硬化が現弱し、免疫活性化状態も正常化した。従って、タイトスキンマウスの皮膚硬化と免疫活性化状態にCD40/CD40L相互作用が関与する事が示唆された。既に、抗CD40L抗体は自己免疫性血小板減少症などに対する使用実績が有るため、今後、全身性強皮症においても新しい治療薬として有用である可能性が考えられた。さらに、全身性強皮症以外の線維化を来す疾患群に対する治療応用も期待された。","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:19790793, 研究期間(年度):2007-2008","subitem_description_type":"Other"},{"subitem_description":"出典：「強皮症モデルマウスの皮膚硬化に対するCD40/CD40L相互作用の解析」研究成果報告書　課題番号19790793\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19790793/19790793seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00056923","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学附属病院"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50401914"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50401914","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19790793/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19790793/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19790793/19790793seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19790793/19790793seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-10"}],"displaytype":"detail","filename":"HO-PR-KOMURA-K-kaken 2009-4p.pdf","filesize":[{"value":"197.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-KOMURA-K-kaken 2009-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/50614/files/HO-PR-KOMURA-K-kaken 2009-4p.pdf"},"version_id":"b2042c15-8367-4a5b-a749-424c9c7b00f8"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"強皮症モデルマウスの皮膚硬化に対するCD40/CD40L相互作用の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"強皮症モデルマウスの皮膚硬化に対するCD40/CD40L相互作用の解析"},{"subitem_title":"CD40/CD40L interactions in a mouse model of systemic sclerosis","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2825"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-02-10"},"publish_date":"2020-02-10","publish_status":"0","recid":"50614","relation_version_is_last":true,"title":["強皮症モデルマウスの皮膚硬化に対するCD40/CD40L相互作用の解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:12:25.347109+00:00"}