{"created":"2023-07-27T06:55:00.002075+00:00","id":50615,"links":{},"metadata":{"_buckets":{"deposit":"d03b5c6b-949d-4565-afa5-3f149e76158d"},"_deposit":{"created_by":18,"id":"50615","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"50615"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00050615","sets":["2812:2813:2821"]},"author_link":["62230","91634"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-05-08","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2012","bibliographic_titles":[{"bibliographic_title":"平成24(2012)年度 科学研究費補助金 研究活動スタート支援 研究成果報告書"},{"bibliographic_title":"2012 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Chujo, Sonoko"}],"nameIdentifiers":[{"nameIdentifier":"62230","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20401911","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20401911"},{"nameIdentifier":"20401911","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000020401911"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ブレオマイシン誘発性強皮症マウスおよびTSK/+マウスにおける抗CTGF抗体の治療効果を検討した。抗CTGF抗体をブレオマイシンと同時に投与した群、ブレオマイシンにより線維化を誘導した後に投与した群、TSK/+マウスに投与した群では、コントロール群に比べ有意に線維化の減少を認めた。以上より、抗CTGF抗体は皮膚線維化を抑制する効果があることが示され、CTGFを直接誘導するのでない動物モデルにおいてもその効果をもたらすことが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"We investigated antifibrotic effect of antibody to connective tissue growth factor (CTGF) in an animal model of skin fibrosis. Anti-CTGF antibody reduced skin fibrosis in a bleomycin-induced scleroderma mouse model and a tight skin mouse. It suggested that anti-CTGF antibody is capable of blocking the development of skin fibrosis in an animal model not induced by exogenous application of growth factors.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:24890076, 研究期間(年度):2012","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「強皮症のモデルマウスにおける抗CTGF抗体の治療効果および作用機序」課題番号24890076\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24890076/24890076seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00056924","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医学部附属病院"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20401911"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20401911","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24890076/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24890076/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24890076/24890076seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24890076/24890076seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中條, 園子"}],"nameIdentifiers":[{"nameIdentifier":"91634","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20401911","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20401911"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-10"}],"displaytype":"detail","filename":"HO-PR-CHUJO-S-kaken 2013-4p.pdf","filesize":[{"value":"279.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-CHUJO-S-kaken 2013-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/50615/files/HO-PR-CHUJO-S-kaken 2013-4p.pdf"},"version_id":"fb28f393-7537-453e-998d-fa4198dced32"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"強皮症のモデルマウスにおける抗CTGF抗体の治療効果および作用機序","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"強皮症のモデルマウスにおける抗CTGF抗体の治療効果および作用機序"},{"subitem_title":"Antifibrotic effect and role of antibody to connective tissue growth factor in an animal model of scleroderma","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2821"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-02-10"},"publish_date":"2020-02-10","publish_status":"0","recid":"50615","relation_version_is_last":true,"title":["強皮症のモデルマウスにおける抗CTGF抗体の治療効果および作用機序"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:55:17.528503+00:00"}