{"created":"2023-07-27T06:55:00.047257+00:00","id":50616,"links":{},"metadata":{"_buckets":{"deposit":"6dc99052-9487-4f0a-b43d-880c19d91795"},"_deposit":{"created_by":18,"id":"50616","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"50616"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00050616","sets":["2812:2813:2820"]},"author_link":["30555","20582"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-19","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2011-2013","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"上咽頭上皮細胞において、Epstein-Barrウイルスの癌蛋白であるLatent membrane protein 1（LMP1）の形質導入により、以下のことが判明した。１）細胞形態および細胞に発現する蛋白のパターンから、転写因子であるTwistおよびsnailを介して上皮間葉移行が誘導されている。２）LMP1発現細胞はCD44高発現、CD24低発現であり、癌幹細胞様表現形式である。したがって、LMP1により癌幹細様形質が獲得されることが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Association of Epstein-Barr virus (EBV) with nasopharyngela carcinoma is know. However, mechanism of nasopharyngeal carcinogenesis is not clarified yet. In the present study, we showed that EBV latent membrane protein 1 (LMP1), a viral oncoprotein, induced a cellular morphorogical change as well as epithelial-mesenchymal transition through transcription factors including Twist and snail in nasopharyngeal epithelial cells. Furthermore, comparison of expression of ABCG2, Nanog, Nestin, Oct4, KLF4 and c-Myc between cells with and without LMP1 expression revealed that LMP1 induced cancer stem/progenitor-like cells in nasopharyngeal epithelial cell lines.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23592522, 研究期間(年度):2011-2013","subitem_description_type":"Other"},{"subitem_description":"出典：「癌幹細胞理論にもとづく上咽頭癌発癌機構の解明」研究成果報告書　課題番号23592522\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23592522/23592522seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00056925","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学附属病院"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20345622"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20345622","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592522/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592522/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23592522/23592522seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23592522/23592522seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-10"}],"displaytype":"detail","filename":"ME-PR-MURONO-S-kaken 2014-5p.pdf","filesize":[{"value":"162.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-MURONO-S-kaken 2014-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/50616/files/ME-PR-MURONO-S-kaken 2014-5p.pdf"},"version_id":"c191ed6a-2c2e-4be2-8be6-8e90b33f68d1"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"癌幹細胞理論にもとづく上咽頭癌発癌機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"癌幹細胞理論にもとづく上咽頭癌発癌機構の解明"},{"subitem_title":"Cancer stem cell model and nasopharyngeal carcinogenesis","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-02-10"},"publish_date":"2020-02-10","publish_status":"0","recid":"50616","relation_version_is_last":true,"title":["癌幹細胞理論にもとづく上咽頭癌発癌機構の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:12:42.993724+00:00"}