{"created":"2023-07-27T06:55:00.093720+00:00","id":50617,"links":{},"metadata":{"_buckets":{"deposit":"fa6f8aab-a580-4576-b8ce-a5412bca8f37"},"_deposit":{"created_by":18,"id":"50617","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"50617"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00050617","sets":["2812:2813:2823"]},"author_link":["30555","20582"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-05-13","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2008-2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"EBウイルス陽性上皮細胞を抗癌剤であるCDDPで処理することにより、EBウイルスの潜伏感染から複製サイクルへのスイッチを担うBZLF1蛋白の発現をウェスタンブロットにより検出した。CDDPによるアポトーシスは認めなかった。CDDPを用いた化学療法を施行された上咽頭癌症例では、化学療法後の組織における組織学的治療効果はグレード0もしくは1であった。免疫染色によるBZLF1蛋白の検出は適切に施行しえなかった。","subitem_description_type":"Abstract"},{"subitem_description":"Treatment of Epstein-Barr virus-positive epithelial cell lines with CDDP, one of anti-cancer drugs, induced BZLF1 protein, which play an important role in switching latent EBV infection to lytic cycle. No clear induction of apoptosis by the drug was observed. In the biopsy specimens taken from post-chemotherapy nasopharyngeal carcinoma patients, histological effect of chemotherapy was grade 0 or 1. On the other hand, immunohistochemistry for BZLF1 could not be properly performed.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"出典：研究課題「抗癌剤によるEBウイルス複製サイクル誘導を利用したあらたな上咽頭癌治療の開発」課題番号20592012\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20592012/20592012seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00056926","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20345622"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20345622","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20592012/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20592012/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20592012/20592012seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20592012/20592012seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-10"}],"displaytype":"detail","filename":"ME-PR-MURONO-S-kaken 2011-4p.pdf","filesize":[{"value":"208.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-MURONO-S-kaken 2011-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/50617/files/ME-PR-MURONO-S-kaken 2011-4p.pdf"},"version_id":"200a3d0b-2df1-4411-836d-e1f8fbbc9857"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"抗癌剤によるEBウイルス複製サイクル誘導を利用したあらたな上咽頭癌治療の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"抗癌剤によるEBウイルス複製サイクル誘導を利用したあらたな上咽頭癌治療の開発"},{"subitem_title":"New therapeutic approach for nasopharyngeal carcinoma using induction of Epstein-Barr virus lytic cycle by anti-cancer chemotherapy","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-02-10"},"publish_date":"2020-02-10","publish_status":"0","recid":"50617","relation_version_is_last":true,"title":["抗癌剤によるEBウイルス複製サイクル誘導を利用したあらたな上咽頭癌治療の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:21:52.890647+00:00"}