{"created":"2023-07-27T06:55:00.319970+00:00","id":50622,"links":{},"metadata":{"_buckets":{"deposit":"b4ac16f0-5cc9-4f46-a7ce-db3d974c50f8"},"_deposit":{"created_by":18,"id":"50622","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"50622"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00050622","sets":["2812:2813:2820"]},"author_link":["24304","91646"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-27","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2011-2013","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究ではテロメラーゼが活性化された細胞でのみ増殖可能な改変型アデノウイルス（Telomerase-specific replication adenovirus:TRAD）が抗癌剤耐性の婦人科癌がん幹細胞候補に対して有効に作用することを示した。\nまたGFP発現型TRADを用いて末梢血中の腫瘍細胞（circulating tumor cells: CTC）を検出した。初発・再発を含む婦人科癌症例での検討において約40％の症例でCTCが認められた。CTCは臨床進行期や病理組織型といった既存の臨床病理学的因子との間には相関は認められなかったが、治療開始後もCTCが存在し続ける症例は予後不良であった。","subitem_description_type":"Abstract"},{"subitem_description":"We have established telomerase-specific replication-selective adenoviruses (TRAD) which can replicate only in telomerase activated cells. In the present study, we assessed the effectiveness of TRAD to the candidates of cancer stem cells in gynecologic cancer.\nWe have also developed a detection system for circulating tumor cells (CTCs) using GFP expressing TRAD. CTCs were detected in 40% of patients with gynecological malignancies. There was no significant correlation between CTC counts and tumor types or known clinicopathological factors, such as clinical stage and histological type. The CTCs rapidly vanished after surgery or chemotherapy in most patients whose treatments were effective. In contrast, the persistence of CTCs even after treatments was tightly associated with poor response to the treatments (P<0.005).","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23592439, 研究期間(年度):2011-2013","subitem_description_type":"Other"},{"subitem_description":"出典：「癌幹細胞を標的とした婦人科癌治療ならびに腫瘍細胞イメージングシステムの構築」研究成果報告書　課題番号23592439\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23592439/23592439seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00056931","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学附属病院"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20313661"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20313661","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592439/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592439/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23592439/23592439seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23592439/23592439seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-10"}],"displaytype":"detail","filename":"HO-PR-TAKAKURA-M-kaken 2014-4p.pdf","filesize":[{"value":"110.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-TAKAKURA-M-kaken 2014-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/50622/files/HO-PR-TAKAKURA-M-kaken 2014-4p.pdf"},"version_id":"6124dfa6-97d6-4c06-92e8-cd711fcba094"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"癌幹細胞を標的とした婦人科癌治療ならびに腫瘍細胞イメージングシステムの構築","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"癌幹細胞を標的とした婦人科癌治療ならびに腫瘍細胞イメージングシステムの構築"},{"subitem_title":"Establishment of cancer virotherapy and imaging system targeting cancer stem cells in gynecologic cancer","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-02-10"},"publish_date":"2020-02-10","publish_status":"0","recid":"50622","relation_version_is_last":true,"title":["癌幹細胞を標的とした婦人科癌治療ならびに腫瘍細胞イメージングシステムの構築"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:12:45.824518+00:00"}