{"created":"2023-07-27T06:55:00.364917+00:00","id":50623,"links":{},"metadata":{"_buckets":{"deposit":"0e17089d-ff92-41dc-ac1c-316ae4100b49"},"_deposit":{"created_by":18,"id":"50623","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"50623"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00050623","sets":["2812:2813:2823"]},"author_link":["24304","91646"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-05-19","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2008-2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"細胞の不死化・癌化に関与するテロメラーゼ発現の決定因子である逆転写酵素hTERTの発現がマイクロRNA miR299-3pによって制御されており,それがhTERTmRNAの特異的な分解促進によるものであることが明らかになった。子宮頚癌では正常子宮頸部と比較してmiR299-3pの発現が減少しており,これがテロメラーゼ活性化を誘導し癌化と関与している可能性が示された。","subitem_description_type":"Abstract"},{"subitem_description":"miRNA miR299-3p is involved in the regulation of telomerase. The degradation of hTERT, the catalytic component of telomerase, mRNA was accelerated by miR299-3p. The decrease of miR299-3p in cervical cancer tissue may be involved in activation of telomerase.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:20591940, 研究期間(年度):2008-2009","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「マイクロRNAによるテロメラーゼ制御機構の解明と子宮頚癌治療への応用」課題番号20591940\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20591940/20591940seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00056932","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20313661"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20313661","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591940/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591940/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20591940/20591940seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20591940/20591940seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-10"}],"displaytype":"detail","filename":"HO-PR-TAKAKURA-M-kaken 2011-5p.pdf","filesize":[{"value":"303.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-TAKAKURA-M-kaken 2011-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/50623/files/HO-PR-TAKAKURA-M-kaken 2011-5p.pdf"},"version_id":"53f35a1b-6c2d-4860-9281-ae294dc44c38"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"マイクロRNAによるテロメラーゼ制御機構の解明と子宮頚癌治療への応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マイクロRNAによるテロメラーゼ制御機構の解明と子宮頚癌治療への応用"},{"subitem_title":"Analysis of miRNA-mediated regulation of telomerase and application for cervical cancer gene therapy","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-02-10"},"publish_date":"2020-02-10","publish_status":"0","recid":"50623","relation_version_is_last":true,"title":["マイクロRNAによるテロメラーゼ制御機構の解明と子宮頚癌治療への応用"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:21:54.188143+00:00"}