{"created":"2023-07-27T06:55:00.546449+00:00","id":50627,"links":{},"metadata":{"_buckets":{"deposit":"01b3c110-f4cb-4c66-8f20-f4358471a242"},"_deposit":{"created_by":18,"id":"50627","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"50627"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00050627","sets":["2812:2813:2822"]},"author_link":["91659","1766"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05-21","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"近年、新しいB細胞サブセットである「制御性B細胞」の免疫反応の調節における重要性が認識されてきた。制御性B細胞の分子メカニズムの解明には特異的マーカーの同定が必須である。本研究は、マウスにおける制御性B細胞の特異的マーカー遺伝子を、網羅的な発現遺伝子解析にて同定することを目的とした。マウスの全遺伝子型DNAチップを用いて、制御性B細胞の発現遺伝子解析を行い、コントロールとの比較により、約180個の候補遺伝子を得ることができた。その中で、約10個の転写制御分子の候補遺伝子の機能を解析中である。","subitem_description_type":"Abstract"},{"subitem_description":"Recently, the important roles of\"regulatory B cells\"in the regulation of immune responses have been widely appreciated. To further clarify the molecular mechanisms of regulatory B cell functions, identification of marker molecules specific for regulatory B cells is necessary. In this study, we have attempted to identify such genes using comprehensive gene expression analysis. We have identified approximately 180 candidate genes. We are currently studying the in vivo and in vitro functions of 10 candidate transcriptional genes among them.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23659544, 研究期間(年度):2011","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「制御性B細胞の特異的マーカー遺伝子の探索」課題番号23659544\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23659544/23659544seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00056936","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=90272591"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=90272591","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659544/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659544/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23659544/23659544seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23659544/23659544seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-10"}],"displaytype":"detail","filename":"ME-PR-FUJIMOTO-M-kaken 2012-4p.pdf","filesize":[{"value":"193.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-FUJIMOTO-M-kaken 2012-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/50627/files/ME-PR-FUJIMOTO-M-kaken 2012-4p.pdf"},"version_id":"5ce63049-6b64-4f3e-a6bf-989247dd1419"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"制御性B細胞の特異的マーカー遺伝子の探索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"制御性B細胞の特異的マーカー遺伝子の探索"},{"subitem_title":"Identification of marker molecules specific for regulatory B cells","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-02-10"},"publish_date":"2020-02-10","publish_status":"0","recid":"50627","relation_version_is_last":true,"title":["制御性B細胞の特異的マーカー遺伝子の探索"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:24:55.885401+00:00"}