{"created":"2023-07-27T06:55:00.591493+00:00","id":50628,"links":{},"metadata":{"_buckets":{"deposit":"d147566e-b198-42ff-af14-d2aa2a2a42e7"},"_deposit":{"created_by":18,"id":"50628","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"50628"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00050628","sets":["2812:2813:2820"]},"author_link":["91587","1766"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-06-08","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2011-04-01 - 2014-03-31","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Fujimoto, Manabu"}],"nameIdentifiers":[{"nameIdentifier":"91587","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90272591","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90272591"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"制御性B細胞におけるIL-10産生のシグナル伝達メカニズムを解析した。BLNKは、B細胞におけるシグナル伝達経路の重要なアダプター分子であるが、BLNKを欠損したマウスでは、Cd1dhiCD5+B細胞からのIL-10産生が欠如しており、接触過敏反応も亢進していた。BLNKを欠損したB細胞では、Stat3の活性化が障害されており、これはBtkの活性に依存していた。さらに、刺激培養条件にIL-10を添加することにより、IL-10産生B細胞の数は著明に増加し、lL-10によるpositive feedback loopの存在が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Signal transduction mechanisms responsible for IL-10 production in regulatory B cells were analyzed. BLNK is an important adaptor protein in B cell signal transduction. B cells from BLNK-deficient mice showed diminished IL-10 production in CD1dhiCD5+ B cells. Accordingly, BLNK-deficient mice exhibited augmented contact hypersensitivity response. CD1dhiCD5+ B cells from BLNK-deficient mice showed impaired Stat3 activation, which was dependent on Btk activity. Moreover, exogenous addition of IL-10 in culture markedly increased the number of IL-10-producing B cells, suggesting the presence of positive feedback loop provided by IL-10 stimulation.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23390281, 研究期間(年度):2011-04-01 - 2014-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「制御性B細胞による皮膚免疫疾患の抑制機構の分子メカニズム」研究成果報告書　課題番号23390281\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23390281/23390281seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00056937","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"筑波大学 / 金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=90272591"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=90272591","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390281/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390281/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23390281/23390281seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23390281/23390281seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"藤本, 学"}],"nameIdentifiers":[{"nameIdentifier":"1766","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90272591","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90272591"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-10"}],"displaytype":"detail","filename":"ME-PR-FUJIMOTO-M-kaken 2014B-5p.pdf","filesize":[{"value":"274.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-FUJIMOTO-M-kaken 2014B-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/50628/files/ME-PR-FUJIMOTO-M-kaken 2014B-5p.pdf"},"version_id":"37e6ca0a-a0de-4986-9c73-f15fb79a2ad2"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"制御性B細胞による皮膚免疫疾患の抑制機構の分子メカニズム","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"制御性B細胞による皮膚免疫疾患の抑制機構の分子メカニズム"},{"subitem_title":"Molecular mechanisms of regulatory B cell inhibition on skin immunological diseases","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-02-10"},"publish_date":"2020-02-10","publish_status":"0","recid":"50628","relation_version_is_last":true,"title":["制御性B細胞による皮膚免疫疾患の抑制機構の分子メカニズム"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:50:06.366750+00:00"}