{"created":"2023-07-27T06:55:01.135936+00:00","id":50646,"links":{},"metadata":{"_buckets":{"deposit":"465465e4-64f5-4f67-a90f-55e2fb93f003"},"_deposit":{"created_by":18,"id":"50646","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"50646"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00050646","sets":["2812:2813:2830"]},"author_link":["91669","91668"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-12","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"77p.","bibliographicVolumeNumber":"2002-2003","bibliographic_titles":[{"bibliographic_title":"平成15(2003)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2003 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"小脳誘発電位(以下CEPs)に関する基礎的研究を行い,以下のような知見を得た.\n1.CEPsは,末梢神経刺激により同側の小脳皮質上に誘発される電位であり,前脊髄動脈潅流域である腹側脊髄小脳路を上行する.\n2.吸入麻酔薬セボフルランの吸入により,体性感覚誘発電位(以下SEPs)は2MAC(4.5%)でも測定可能であったが,運動野誘発電位(以下MEPs)は0.5%でも消失した.CEPsは,1MAC(2.5%)までは測定可能であった.\n3.静脈麻酔薬プロポフォールの投与では,体性感覚誘発電位(以下SEPs)はED50(30mg/kg/hour)でも測定可能であったが,MEPsは5mg/kg/hourでも消失した.CEPsは,30mg/kg/hourまでは測定可能であったが,振幅が著しく小さくなるため感度を上げる必要があった.\n4.5分間の脊髄虚血により,SEPsは振幅が10%程度小さくなったが虚血解除により速やかに回復した.MEPsは完全に消失してしまい波形が再出現するまでに15分を要した.CEPsでは虚血により振幅は50%以下にまで小さくなるが虚血解除により速やかにもとの大きさに復した.\n5.10分間の脊髄虚血により,SEPsは波形が消失したが虚血解除により速やかに回復した.MEPsは完全に消失してしまい波形は再出現しなかった。CEPsでは虚血により波形は消失し,波形が再出現するのに約10分間を要した.10分虚血群では全例が下肢麻痺となった.\n以上より,CEPsは麻酔薬の制限の少ない脊髄虚血モニター法として有望であり,今後臨床研究を実施する予定である.","subitem_description_type":"Abstract"},{"subitem_description":"I have conducted basic researches about cerebellar evoked potentials (CEPs) and obtained the following findings;\n1.CEPs is evoked on ipsilateral cereballar cortex by a peripheral nerve electrical stimulation, the stimulus ascends through the ventral spinocerebellar tracts in the area perfused by the anterior spinal artery.\n2.Somatosenroy evoked potentials (SEPs) was recorded even under 2 MAC of sevoflurane, while motor evoked potentials (MEPs) had been faded away under 0.25 MAC of sevoflurane. CEPs could be recorded at 1.0 MAC of sevoflurane.\n3.SEPs was recorded even under ED50 (30mg/kg/hour) of propofol, while MEPs had been faded away under 5mg/kg/hour of propofol. CEPs could be recorded at ED50 of propofol, but its amplitude was small.\n4.Five min spinal ischemia reduced the amplitude of SEPs by 10%, but it recovered immediately after reperfusion, while MEPs disappeared by spinal ischemia and it required about 15 min to reemerge. The amplutude of CEPs was reduced by 50% during spinal ischemia, and it recovered promptly by reperfusion. No animals showed motor function deficiency.\n5.Ten min spinal ischemia had extinguished all potentials. SEPs and CEPs reemerged 2 and 10 min after reperfusion, respectively, while MEPs was not recorded even 1 hour after reperfusion. All animals showed paraplegia.\nIn conclusion, CEPs is more sensitive to spinal ischemia than SEPs, and less restrictive about anesthetic drugs selection than MEPs. Clinical trials are necessary to prove usefulness of CEPs.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:14571424, 研究期間(年度):2002-2003","subitem_description_type":"Other"},{"subitem_description":"出典：「小脳誘発電位の基礎的研究ならびに臨床麻酔への応用」研究成果報告書　課題番号14571424\n  (KAKEN：科学研究費助成事業データベース（国立情報学研究所）)\n　　　本文データは著者版報告書より作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00056955","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80283109"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80283109","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14571424/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14571424/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-14571424/145714242003kenkyu_seika_hokoku_gaiyo/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-14571424/145714242003kenkyu_seika_hokoku_gaiyo/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-21"}],"displaytype":"detail","filename":"ME-PR-TSUBOKAWA-T-kaken 2004-77p.pdf","filesize":[{"value":"9.8 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-TSUBOKAWA-T-kaken 2004-77p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/50646/files/ME-PR-TSUBOKAWA-T-kaken 2004-77p.pdf"},"version_id":"ba7ced64-727d-4826-a67d-246d20b65556"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"小脳誘発電位の基礎的研究ならびに臨床麻酔への応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"小脳誘発電位の基礎的研究ならびに臨床麻酔への応用"},{"subitem_title":"Basic and clinical researches about cerebellar evoked potentials","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2830"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-02-21"},"publish_date":"2020-02-21","publish_status":"0","recid":"50646","relation_version_is_last":true,"title":["小脳誘発電位の基礎的研究ならびに臨床麻酔への応用"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:37:02.765248+00:00"}