{"created":"2023-07-27T06:55:03.407868+00:00","id":50704,"links":{},"metadata":{"_buckets":{"deposit":"676dca76-02cb-4a23-b3b0-784688cf9c43"},"_deposit":{"created_by":18,"id":"50704","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"50704"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00050704","sets":["2812:2813:2822"]},"author_link":["91808","1928"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05-18","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2009-2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"胆汁酸受容体の一つfarnesoid X receptorのアンタゴニストであるガグルステロン(GS)が、バレット食道癌の発癌過程を抑制できるか否かを、ラット胃全摘後十二指腸食道逆流モデルを用いて検討した。ラットをGS高投与群、GS低投与群、非投与群の3群に分けて、20, 40, 50週目に屠殺し検討した。過形成、円柱上皮化生、異形成、癌の発生率は、いずれの時期においても、3群間で差が認められなかった。以上より、GSは本モデルにおいてバレット食道腺癌の発癌を予防できないと考えられた。","subitem_description_type":"Abstract"},{"subitem_description":"We examined chemopreventive effect of gugglesterone(GS), an antagonist of farnesoid X receptor, on Barrett's esophageal cancer using rodent duodenoesophageal reflux model. Animals were divided into 3 groups, high GS group, low GS group and control and sacrificed 20, 40, 50 weeks after operation. There were no significant differences between 3 groups in the incidences of hyperplasia, columnar epithelia, dysplasia, and carcinoma in all terms. These results suggested that GS had no preventive effect on the esophagocarcinogenesis in this model.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:21591695, 研究期間(年度):2009-2011","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「胆汁酸受容体FXR阻害によるバレット食道腺癌の化学予防」課題番号21591695\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21591695/21591695seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057012","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医学系研究科"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50262580"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50262580","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591695/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591695/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21591695/21591695seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21591695/21591695seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-14"}],"displaytype":"detail","filename":"ME-PR-FUJIWARA-K-kaken 2012-4p.pdf","filesize":[{"value":"232.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-FUJIWARA-K-kaken 2012-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/50704/files/ME-PR-FUJIWARA-K-kaken 2012-4p.pdf"},"version_id":"66a8f580-d8b1-4fe0-a303-40891d13007d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"胆汁酸受容体FXR阻害によるバレット食道腺癌の化学予防","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"胆汁酸受容体FXR阻害によるバレット食道腺癌の化学予防"},{"subitem_title":"Chemoprevention for Barrett's esophageal adenocarcinogenesis by inhibiting bile acid receptor, FXR","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-02-14"},"publish_date":"2020-02-14","publish_status":"0","recid":"50704","relation_version_is_last":true,"title":["胆汁酸受容体FXR阻害によるバレット食道腺癌の化学予防"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:24:57.101049+00:00"}