{"created":"2023-07-27T06:55:03.588770+00:00","id":50715,"links":{},"metadata":{"_buckets":{"deposit":"b0ffb3d8-661a-4daf-a9cd-c66a6493012d"},"_deposit":{"created_by":18,"id":"50715","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"50715"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00050715","sets":["2812:2813:2831"]},"author_link":["91830","20109"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-04-13","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"2p.","bibliographicVolumeNumber":"2000-2002","bibliographic_titles":[{"bibliographic_title":"平成14(2002)年度 科学研究費補助金 基盤研究(C) 研究成果報告書概要"},{"bibliographic_title":"2002 Fiscal Year Final Research Report Summary","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tachino, Katsuhiko"}],"nameIdentifiers":[{"nameIdentifier":"91830","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40092788","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40092788"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"部分脱神経筋(PD)の神経および筋の回復機序については未だ不明な点が多い。PDの作成についても多くの問題点があって、実験結果についても一致を見ない。さらに現在までの多くの報告は、筋接合部での観察であり、神経および筋自体の病態像を捉えた報告はない。本実験でのPDは、第5腰髄神経節を切離し、恒常的なPDを作成した。部分脱神経を起こした神経の本幹部分での観察およびヒラメ筋の湿重量、筋線維横断面積、筋線維のタイプ分類を調べた。PD後の神経本幹部分において、残存した正常な神経束の髄鞘内横断面積は4週目と6週目に増大した。PD後の筋力回復は、脱神経後6週までは残存した筋線維の廃用性筋萎縮と発芽による再支配を受けた筋群の肥大によることが明らかとなった。術後6週目以後は、代償的に肥大する筋群と術後6週目まで脱神経のまま残存した筋線維の肥大によることが判明した。\nさらにPD後のトレーニングが神経筋形態学的変化について調べた。髄鞘内横断面積は2週間のトレーニングにより減少させ、筋横断面積は2週目および6週目において大きな線維の増加が観察された。\nまたPD後に廃用性筋萎縮をおこさせるため下肢懸垂をおこなった。PDに寡運動を加えると脱神経筋線維の横断面積は緩徐に萎縮が進むことが判明した。","subitem_description_type":"Abstract"},{"subitem_description":"The effects of partial denervation of the rat soleus and sciatic nerve were studied by resecting the right L5 nerve. The cross-sectinal areas of sciatic nerves and soleus muscles were examined with respect to the changes in muscle fiber types. The sciatic nerves and soleus muscles were removed 2,4,6 and 8 weeks after the operation. The soleus muscles were weighed immediately after removal and stained with routine ATPase staining, followed by examination of changes in type classification (Type II /Total muscle fibers) and cross-sectional areas. The cross-sectinal myelinated areas did not change in the control group. For the partial denervation group, an increase in the cross-sectional areas at 4 and 6 weeks were seen. An overall decrease in corerected muscle weight (soleus muscle weight mg/body weight g) was seen in the partial denervation group, but no changes were seen throughout the experimental week. The distribution of the cross-sectional area in partial denervated soleus muscle was shifted to the left at 2 weeks. The distribution began to par shift to the right at 4 weeks and there were biphasic left- and right-shifted groups at 6 weeks. Finally, the whole denervated group had shifted to the right by 8 weeks. The distribution of denervated muscles remained even throughout the 8 weeks. These findings indicate that, in the partially denervated muscle, recovery of the muscle atrophied through disuse and reinnervated muscle occurs first, followed by recovery of the remaining partially denervated muscle.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:12832017, 研究期間(年度):2000-2002","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「神経・筋のinteraction-部分脱神経筋の回復過程の機序」課題番号12832017\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-12832017/128320172002kenkyu_seika_hokoku_gaiyo/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057023","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=40092788"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=40092788","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12832017/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12832017/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-12832017/128320172002kenkyu_seika_hokoku_gaiyo/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-12832017/128320172002kenkyu_seika_hokoku_gaiyo/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"立野, 勝彦"}],"nameIdentifiers":[{"nameIdentifier":"20109","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40092788","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40092788"},{"nameIdentifier":"40092788","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000040092788"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-19"}],"displaytype":"detail","filename":"ME-PR-TACHINO-K-kaken 2004-2p.pdf","filesize":[{"value":"81.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-TACHINO-K-kaken 2004-2p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/50715/files/ME-PR-TACHINO-K-kaken 2004-2p.pdf"},"version_id":"f786f877-4c98-416e-baf7-615706afdf5b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"神経・筋のinteraction-部分脱神経筋の回復過程の機序","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"神経・筋のinteraction-部分脱神経筋の回復過程の機序"},{"subitem_title":"Interaction of Norves and Muscles After Partial Denervation","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2831"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-05-19"},"publish_date":"2022-05-19","publish_status":"0","recid":"50715","relation_version_is_last":true,"title":["神経・筋のinteraction-部分脱神経筋の回復過程の機序"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T06:26:25.324576+00:00"}